Journal article
Early outcomes after definitive chemoradiation therapy with Vienna/Venezia hybrid high-dose rate brachytherapy applicators for cervical cancer: A single-institution experience
Brachytherapy, v 20(1), pp 104-111
Jan 2021
PMID: 32952053
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Vienna and Venezia (Elekta) are hybrid intracavitary/interstitial brachytherapy (BT) applicators for cervical cancers unsuitable for intracavitary BT alone to improve target coverage or reduce critical organ dose. There is limited outcome data with the use of these applicators outside published experience of the EMBRACE group. We report feasibility and early outcomes with the use of these hybrid applicators at our institution.
Hybrid applicators were used to treat 61 patients with cervical cancer from November 2011 to December 2019. Indications for hybrid applicator use were involvement of the vagina in 10 patients (16%), residual central or parametrial disease in 46 patients (75%), and a narrow introitus in 5 patients (9%). Toxicities were graded using the CTCAE v4.0. Outcomes were assessed with the Kaplan–Meier method.
Median follow-up was 16 months (IQR 9–32 mos). Median HRCTV volume was 31.6 cm3 (IQR 25–48 cm3). Median HRCTV D90 was 86.1 Gy (IQR 84.3–88.0 Gy). In 54 patients with follow-up PET/CT at 3 months, complete initial imaging response locally was seen in 46 patients.Estimated 12-month Kaplan–Meier overall survival, locoregional control, distant control, and recurrence-free survival estimates were 86.9%, 80.6%, 73.8%, and 65.9%, respectively. The 12-month incidence of Grade 3+ GI/GU chronic toxicities was 5.7%, consisting of vesicovaginal fistula, rectovaginal fistula, and ureterovesical fistula.
Our single-institution data support the use of the hybrid applicators, as an alternative to traditional BT applicators when clinically warranted. Use of hybrid applicators is feasible with adequate coverage of disease in the vagina and parametrium.
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Details
- Title
- Early outcomes after definitive chemoradiation therapy with Vienna/Venezia hybrid high-dose rate brachytherapy applicators for cervical cancer: A single-institution experience
- Creators
- A. Keller - UPMC Hillman Cancer CenterJ.L. Rodríguez-López - UPMC Hillman Cancer CenterA.K. Patel - UPMC Hillman Cancer CenterJ.A. Vargo - UPMC Hillman Cancer CenterH. Kim - UPMC Hillman Cancer CenterC.J. Houser - UPMC Hillman Cancer CenterP. Sukumvanich - Magee-Womens HospitalJ.L. Berger - Magee-Womens HospitalM.M. Boisen - Magee-Womens HospitalR.P. Edwards - Magee-Womens HospitalS.E. Taylor - Magee-Womens HospitalM.B. Courtney-Brooks - Magee-Womens HospitalB.C. Orr - Magee-Womens HospitalA.B. Olawaiye - Magee-Womens HospitalS. Beriwal - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 20(1), pp 104-111
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000614556100013
- Scopus ID
- 2-s2.0-85091082773
- Other Identifier
- 991021897280004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging