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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Economic impacts of alternative kidney transplant immunosuppression: A national cohort study
CLINICAL TRANSPLANTATION, v 34(4), e13813
Apr 2020
PMID: 32027049
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Understanding the economic implications of induction and maintenance immunosuppression (ISx) is important in developing personalized kidney transplant (KTx) care. Using data from a novel integrated data set including financial records from the University Health System Consortium, Medicare, and pharmacy claims (2007-2014), we estimated the differences in the impact of induction and maintenance ISx regimens on transplant hospitalization costs and Medicare payments from KTx to 3 years. Use of thymoglobulin (TMG) significantly increased transplant hospitalization costs ($12 006; P = .02), compared with alemtuzumab and basiliximab. TMG resulted in lower Medicare payments in posttransplant years 1 (-$2058; P = .05) and 2 (-$1784; P = .048). Patients on steroid-sparing ISx incurred relatively lower total Medicare spending (-$10 880; P = .01) compared with patients on triple therapy (tacrolimus, antimetabolite, and steroids). MPA/AZA-sparing, mammalian target of rapamycin inhibitors-based, and cyclosporine-based maintenance ISx regimens were associated with significantly higher payments. Alternative ISx regimens were associated with different KTx hospitalization costs and longer-term payments. Future studies of clinical efficacy should also consider cost impacts to define the economic effectiveness of alternative ISx regimens.
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Details
- Title
- Economic impacts of alternative kidney transplant immunosuppression: A national cohort study
- Publication Details
- CLINICAL TRANSPLANTATION, v 34(4), e13813
- Publisher
- WILEY; HOBOKEN
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000528798200009
- Scopus ID
- 2-s2.0-85081374963
- Other Identifier
- 991021860767604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery
- Transplantation