Journal article
Effect of Age, Gender, Rat Strain, and Dietary Restriction, on Norepinephrine Release From Cardiac Synaptosomes
The journals of gerontology. Series A, Biological sciences and medical sciences, v 53A(1), pp B33-B41
Jan 1998
PMID: 9467420
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of the present study was to determine if dietary restriction affected NE release from cardiac synaptosomes obtained from old male F344 rats. Female F344 rats and male and female B/N rats were also examined to determine if age-related changes in norepinephrine (NE) release capacity in the heart are strain- and/or genderspecific. F344 and Brown-Norway (B/N) rats were examined at 6,12, and 24 months; B/N rats were also examined at 28–30 months. K+-induced NE release significantly declined with age in male F344 and B/N rats; this decline was attenuated in female rats and in dietary restricted rats, especially at 24 months. The present study demonstrates that aging reduces the capacity of cardiac adrenergic nerve terminals to release NE, this age-related change is not strain specific, and that dietary restriction and gender alter the extent of this change with age.
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Details
- Title
- Effect of Age, Gender, Rat Strain, and Dietary Restriction, on Norepinephrine Release From Cardiac Synaptosomes
- Creators
- David L. Snyder - Allegheny University of the Health SciencesPamela A. Gayheart-Walsten - Allegheny University of the Health SciencesSangho Rhie - Department of Thoracic and Cardiovascular Surgery, College of Medicine, Gyeongsang National University KoreaWenjing Wang - Allegheny University of the Health SciencesJay Roberts - Allegheny University of the Health SciencesJames R Roberts - Emergency Medicine
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, v 53A(1), pp B33-B41
- Publisher
- The Gerontological Society of America
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:000071712800005
- Scopus ID
- 2-s2.0-0031917932
- Other Identifier
- 991019168974904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology