Journal article
Effect of Age on Response to Amblyopia Treatment in Children
Archives of ophthalmology (1960), v 129(11), pp 1451-1457
01 Nov 2011
PMID: 21746970
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To determine whether age at initiation of treatment for amblyopia influences the response among children 3 to less than 13 years of age with unilateral amblyopia who have 20/40 to 20/400 amblyopic eye visual acuity.
Methods: A meta-analysis of individual subject data from 4 recently completed randomized amblyopia treatment trials was performed to evaluate the relationship between age and improvement in logMAR amblyopic eye visual acuity. Analyses were adjusted for baseline amblyopic eye visual acuity, spherical equivalent refractive error in the amblyopic eye, type of amblyopia, prior amblyopia treatment, study treatment, and protocol. Age was categorized (3 to <5 years, 5 to <7 years, and 7 to <13 years) because there was a nonlinear relationship between age and improvement in amblyopic eye visual acuity.
Results: Children from 7 to less than 13 years of age were significantly less responsive to treatment than were younger age groups (children from 3 to <5 years of age or children from 5 to <7 years of age) for moderate and severe amblyopia (P<.04 for all 4 comparisons). There was no difference in treatment response between children 3 to less than 5 years of age and children 5 to less than 7 years of age for moderate amblyopia (P =. 67), but there was a suggestion of greater responsiveness in children 3 to less than 5 years of age compared with children 5 to less than 7 years of age for severe amblyopia (P =. 09).
Conclusions: Amblyopia is more responsive to treatment among children younger than 7 years of age. Although the average treatment response is smaller in children 7 to less than 13 years of age, some children show a marked response to treatment.
Metrics
Details
- Title
- Effect of Age on Response to Amblyopia Treatment in Children
- Creators
- Jonathan M. Holmes - Mayo ClinicElizabeth L. Lazar - Jaeb Ctr Hlth Res, Tampa, FL 33647 USAB. Michele Melia - Jaeb Ctr Hlth Res, Tampa, FL 33647 USAWilliam F. Astle - Alberta Childrens Prov Gen Hosp, Dept Ophthalmol, Calgary, AB, CanadaLinda R. Dagi - Childrens Hosp Boston, Dept Ophthalmol, Boston, MA USASean P. Donahue - Vanderbilt Eye Ctr, Nashville, TN USAMarcela G. Frazier - University of AlabamaRichard W. Hertle - Childrens Hosp Pittsburgh, Div Pediat Ophthalmol, Pittsburgh, PA USAMichael X. Repka - Johns Hopkins UniversityGraham E. Quinn - Childrens Hosp Philadelphia, Div Pediat Ophthalmol, Philadelphia, PA USAKatherine K. Weise - University of AlabamaPediat Eye Dis Investigator GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Archives of ophthalmology (1960), v 129(11), pp 1451-1457
- Publisher
- Amer Medical Assoc
- Number of pages
- 7
- Grant note
- EY011751; EY018810 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Research to Prevent Blindness, New York; Research to Prevent Blindness (RPB) U10EY018810 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000297047600008
- Scopus ID
- 2-s2.0-81355164224
- Other Identifier
- 991021900613304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology