Journal article
Effect of Bariatric Surgery on Disease Outcomes in Patients With Inflammatory Bowel Disease
Journal of clinical gastroenterology, v 58(5), pp 447-453
01 May 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction and Aim:A growing body of evidence suggests a negative impact of obesity on the disease activity of inflammatory bowel disease (IBD). The primary aim of the study was to evaluate disease outcomes of IBD in patients after bariatric surgery (BS).Methods:Patients with IBD and morbid obesity who underwent BS were compared with patients with IBD and morbid obesity without BS in a retrospective, propensity-score matched cohort study using TriNetX, a multi-institutional database. The primary aim was to assess the 2-year risk of a composite of disease-related complications, which included intravenous steroid use or IBD-related surgery. Risk was expressed as adjusted odds ratios (aOR) with 95% confidence intervals (CI).Results:In all, 482 patients (3.4%) with IBD and morbid obesity underwent BS (mean age 46.9 +/- 11.2 y old, mean BMI 42.1 +/- 7.72 kg/m2, Crohn's disease 60%). After propensity-score matching, the BS cohort had a lower risk (aOR 0.31, 95% CI 0.17-0.56) of a composite of IBD-related complications compared with the control cohort. After propensity-score matching, the BS cohort with sleeve gastrectomy had a decreased risk (aOR 0.45, 95% CI 0.31-0.66) of a composite of IBD-related complications. There was no difference in the risk (aOR 0.77, 95% CI 0.45-1.31) of a composite of IBD-related complications between the BS cohort with Roux-en-Y gastric bypass (RYGB) compared with the control cohort.Conclusion:Sleeve gastrectomy but not Roux-en-Y gastric bypass is associated with improved disease-specific outcomes in patients with IBD and morbid obesity.
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Details
- Title
- Effect of Bariatric Surgery on Disease Outcomes in Patients With Inflammatory Bowel Disease
- Creators
- Aakash Desai - Case Western Reserve UniversityJana G. Hashash - Jacksonville CollegeGianna Baker - Allegheny Health NetworkFrancis A. Farraye - Jacksonville CollegeNisheet Waghray - Case Western Reserve UniversityGursimran S. Kochhar - Allegheny Health Network
- Publication Details
- Journal of clinical gastroenterology, v 58(5), pp 447-453
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001197487000007
- Other Identifier
- 991022135629904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology