Journal article
Effect of Chronic Lithium Treatment on 5‐Hydroxytryptamine Autoreceptors and Release of 5‐[3H]Hydroxytryptamine from Rat Brain Cortical, Hippocampal, and Hypothalamic Slices
Journal of neurochemistry, v 50(1)
Jan 1988
PMID: 2826685
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Abstract
: The effect of acute and chronic lithium treatments on 5‐hydroxytryptamine (5‐HT, serotonin) release and on its regulation by presynaptic 5‐HT autoreceptors was studied in [3H]5‐HT preloaded superfused rat brain slices. The [3H]5‐HT overflow evoked by a 30‐s exposure to 65 mM K+ was increased after 3 weeks of ingestion of lithium‐containing diet in the three brain areas examined. Acute injection of 4 mEq/kg lithium chloride did not affect 5‐HT release. The K+‐induced release observed in both control and chronically lithium‐treated animals was Ca2+‐dependent. Chronic lithium treatment was also found to be associated with a decrease in basal [3H]5‐HT overflow in the cortex and hypothalamus and with an increase in spontaneous hippocampal 5‐HT overflow. The Ca2+‐independent overflow induced by fenfluramine was also decreased in cortical slices from lithium‐treated animals. The sensitivity of the inhibitory 5‐HT autoreceptors was assessed by the response to the 5‐HT agonist 5‐methoxytryptamine. The results indicate a marked reduction in the maximal inhibition of [3H]5‐HT release induced by 5‐methoxytryptamine in slices obtained from animals which have been treated with lithium for 3 weeks. These data suggest that the functional down regulation of the prejunctional 5‐HT sites may be responsible for the increase in K+‐stimulated 5‐HT overflow in brain slices of animals treated chronically with lithium.
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Details
- Title
- Effect of Chronic Lithium Treatment on 5‐Hydroxytryptamine Autoreceptors and Release of 5‐[3H]Hydroxytryptamine from Rat Brain Cortical, Hippocampal, and Hypothalamic Slices
- Creators
- Eitan Friedman - York College of PennsylvaniaHoau‐Yan Wang
- Publication Details
- Journal of neurochemistry, v 50(1)
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1988L268800029
- Scopus ID
- 2-s2.0-0023837346
- Other Identifier
- 991019184175804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences