Journal article
Effect of Fatigue on Health-Related Quality of Life and Work Productivity in Psoriatic Arthritis: Findings From a Real-World Survey
JOURNAL OF RHEUMATOLOGY, v 49(11), p1221
01 Nov 2022
PMID: 35840154
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. To evaluate fatigue frequency and severity among patients with psoriatic arthritis (PsA) and assess the effect of fatigue severity on patient-reported outcome measures (PROMs) assessing quality of life, function, and work productivity. Methods. Data were derived from the Adelphi Disease Specific Programme, a cross-sectional survey conducted in 2018 in the United States and Europe. Patients had physician-confirmed PsA. Fatigue was collected as a binary variable and through its severity (0-10 scale, using the 12-item Psoriatic Arthritis Impact of Disease fatigue question) from patients; physicians also reported patient fatigue (yes/no). Other PROMs included the 5-level EuroQol 5-dimension questionnaire (EQ-5D-5L) for health-related quality of life (HRQOL), Health Assessment Questionnaire-Disability Index, and Work Productivity and Activity Impairment Questionnaire. Multivariate linear regression was used to evaluate the association between fatigue severity and other PROMs. Results. Among the 831 included patients (mean age 47.5 yrs, mean disease duration 5.3 yrs, 46.9% female, 48.1% receiving a biologic), fatigue was reported by 78.3% of patients. Patients with greater fatigue severity had greater disease duration, PsA severity, pain levels, body surface area affected by psoriasis, and swollen and tender joint counts (all P < 0.05). In multivariate analyses, patients with greater fatigue severity experienced worse physical functioning, HRQOL, and work productivity (all P < 0.001). Presence of fatigue was under-reported by physicians (reported in only 32% of patients who self-reported fatigue). Conclusion. Prevalence of patient-reported fatigue was high among patients with PsA and underrecognized by physicians. Fatigue severity was associated with altered physical functioning, work productivity, and HRQOL.
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Details
- Title
- Effect of Fatigue on Health-Related Quality of Life and Work Productivity in Psoriatic Arthritis: Findings From a Real-World Survey
- Publication Details
- JOURNAL OF RHEUMATOLOGY, v 49(11), p1221
- Publisher
- J RHEUMATOL PUBL CO; TORONTO
- Grant note
- Medical writing support under the guidance of the authors was provided by Carole Evans, PhD, on behalf of Adelphi Real World and Janssen, and was funded by Janssen in accordance with Good Publication Practice (GPP3) guidelines.40 All authors were involved in (1) conception or design, or analysis and interpretation of data; (2) drafting and revising the article; (3) providing intellectual content of critical importance to the work described; and (4) final approval of the version to be published, and therefore meet the criteria for authorship in accordance with the guidelines of the International Committee of Medical Journal Editors.41 In addition, all named authors take responsibility for the integrity of the work as a whole and have given their approval for this version to be published.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001043924600008
- Scopus ID
- 2-s2.0-85141067692
- Other Identifier
- 991021860733404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology