Journal article
Effect of Fractionation in Stereotactic Body Radiation Therapy Using the Linear Quadratic Model
International journal of radiation oncology, biology, physics, v 86(1)
01 May 2013
PMID: 23245283
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To examine the fractionation effect of stereotactic body radiation therapy with a heterogeneous dose distribution.
Methods: Derived from the linear quadratic formula with measurements from a hypothetical 2-cm radiosurgical tumor, the threshold percentage was defined as (alpha/beta(tissue)/alpha/beta(tumor)), the balance alpha/beta ratio was defined as (prescription dose/tissue tolerance*alpha/beta(tumor)), and the balance dose was defined as (tissue tolerance/threshold percentage).
Results: With increasing fractions and equivalent peripheral dose to the target, the biological equivalent dose of "hot spots" in a target decreases. The relative biological equivalent doses of serial organs decrease only when the relative percentage of its dose to the prescription dose is above the threshold percentage. The volume of parallel organs at risk decreases only when the tumor's alpha/beta ratio is above the balance alpha/beta ratio and the prescription dose is lower than balance dose.
Conclusions: The potential benefits of fractionation in stereotactic body radiation therapy depend on the complex interplay between the total dose, alpha/beta ratios, and dose differences between the target and the surrounding normal tissues. (C) 2013 Elsevier Inc.
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Details
- Title
- Effect of Fractionation in Stereotactic Body Radiation Therapy Using the Linear Quadratic Model
- Creators
- Jun Yang - Drexel UniversityJohn Lamond - Drexel UniversityJack Fowler - University of Wisconsin–MadisonRachelle Lanciano - Drexel UniversityJing Feng - Drexel UniversityLuther Brady - Drexel University
- Publication Details
- International journal of radiation oncology, biology, physics, v 86(1)
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000317345700031
- Scopus ID
- 2-s2.0-84876151921
- Other Identifier
- 991019168913004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging