Journal article
Effect of Lithium on Reproduction and Postnatal Growth of Mice
Neonatology (Basel, Switzerland), v 43(5-6), 287
1983
PMID: 6871297
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mating pairs of mice were maintained continuously on drinking water containing 50 mEq/l LiCl and its effects on reproduction and postnatal development were monitored. In mating pairs put on lithium at 6–8 weeks of age, the lithium does not appear to reduce litter size at birth but it does increase postnatal mortality and the length of time between litters, and reduces the total number of litters a mating pair may have. In mating pairs put on lithium at 3 weeks of age, it severely delays postnatal growth and development of all pups in the litter. With the exception of the liver, this delayed growth and development does not appear to affect internal organs as severely as somatic body parts. This delayed growth may be the result of some effect lithium may have on certain hormones such as prolactin, thyroxine and growth hormone.
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Details
- Title
- Effect of Lithium on Reproduction and Postnatal Growth of Mice
- Creators
- Deborah L. MroczkaKenneth M. HoffCecilie A. GoodrichPeter C. Baker
- Publication Details
- Neonatology (Basel, Switzerland), v 43(5-6), 287
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1983QT67400012
- Scopus ID
- 2-s2.0-0020584380
- Other Identifier
- 991021230005904721
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- Web of Science research areas
- Pediatrics