Journal article
Effect of Mitomycin C on Recurrence of Ganglion Cysts in the Foot and Ankle
JOURNAL OF FOOT & ANKLE SURGERY, v 59(5), pp 903-908
Sep 2020
PMID: 32475655
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ganglion cysts are among the most common benign soft tissue masses. Although surgery has been shown to be effective, similar to 12% to 42% of cases with long-term follow-up have been reported to recur. The purpose of this study was to determine the impact of the topical application of mitomycin C used as an adjuvant to surgery on recurrence rate of ganglion cysts. A retrospective analysis was done on all patients surgically treated by 1 surgeon for ganglion cysts. The primary end point was local recurrence after the procedure, determined clinically and by ultrasound. Secondary outcomes included wound complication rate, adverse effects, and overall patient satisfaction. A total of 98 consecutive patients were included in this study and assigned to a study group in a nonrandomized manner. The control group (n = 52) consisted of patients who underwent surgical resection only. The study group (n = 46) consisted of patients who underwent surgical resection with application of topical mitomycin C. No patients were lost to follow-up. Of the 52 patients in the control group, 13 (25.0%) had recurrence of the ganglion cyst. In contrast, in the experimental study group, 2 patients (4.3%) had a recurrence. There was no difference in superficial wound infections between the 2 groups. In this study, we found that the use of topical mitomycin C as an adjuvant to surgical resection significantly reduced the recurrence rate. Wound infection and overall nonrecurrence complication rates were similar to those of other studies. (C) 2020 by the American College of Foot and Ankle Surgeons. All rights reserved.
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Details
- Title
- Effect of Mitomycin C on Recurrence of Ganglion Cysts in the Foot and Ankle
- Publication Details
- JOURNAL OF FOOT & ANKLE SURGERY, v 59(5), pp 903-908
- Publisher
- ELSEVIER SCIENCE INC; NEW YORK
- Number of pages
- 0
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000571794200016
- Scopus ID
- 2-s2.0-85085567215
- Other Identifier
- 991021860680704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics
- Surgery