Journal article
Effect of Nutrition on Statural Growth
Hormone research in paediatrics, v 88(1)
2017
PMID: 28365689
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In children, proper growth and development are often regarded as a surrogate marker for good health. A complex system controls the initiation, rate, and cessation of growth, and thus gives a wonderful example of the interactions between genetics, epigenetics, and environmental factors (especially stress and nutrition). Malnutrition is considered a leading cause of growth attenuation in children. This review summarizes our current knowledge regarding the mechanisms linking nutrition and skeletal growth, including systemic factors, such as insulin, growth hormone, insulin-like growth factor-1, fibroblast growth factor-21, etc., and local mechanisms, including mTOR, miRNAs, and epigenetics. Studying the molecular mechanisms regulating skeletal growth may lead to the establishment of better nutritional and therapeutic regimens for more effective linear growth in children with malnutrition and growth abnormalities.
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Details
- Title
- Effect of Nutrition on Statural Growth
- Creators
- Galia Gat-Yablonski - a,b,cFrancesco De Luca - St. Christopher's Hospital for ChildrenFrancesco DeLuca - Pediatrics
- Publication Details
- Hormone research in paediatrics, v 88(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000407926900006
- Scopus ID
- 2-s2.0-85018421036
- Other Identifier
- 991019168581404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Pediatrics