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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Effect of Positive Well-Being on Incidence of Symptomatic Coronary Artery Disease
The American journal of cardiology, v 112(8), pp 1120-1125
15 Oct 2013
PMID: 23810324
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While negative emotions and psychiatric morbidity have often been found to increase incident coronary artery disease (CAD) risk, fewer studies have shown positive emotions to be protective against CAD; none have been performed in high-risk healthy populations, taking risk factors into account. Thus, we examined the impact of positive well-being on incident CAD in both a high-risk initially healthy population and in a national probability sample. We screened healthy siblings of probands with documented early-onset CAD from 1985 to 2007 in the GeneSTAR (Genetic Study of Atherosclerosis Risk) population and examined sociodemographics, risk factors, and positive well-being using the General Well Being Schedule (GWBS). We further classified siblings into high, intermediate and low risk strata based on the Framingham Risk Score (FRS) and followed them for 5 to 25 years. Siblings (n=1483) with higher baseline GWBS total scores were significantly less likely to develop CAD (hazard ratio [HR]=0.67, 95% confidence interval [CI] 0.58–0.79), independent of age, sex, race, and traditional risk factors. Protection was strongest in the high FRS stratum (HR=0.52, 95% CI 0.30–0.90). Findings were replicated in the first National Health and Nutrition Examination Survey and Epidemiologic Follow-up Study (n=5992; HR=0.87, 95% CI 0.83–0.93). In conclusion, positive well-being was associated with nearly a third reduction in CAD in a high-risk population with family history, a nearly 50% reduction in incident CAD in the highest risk stratum in those with family history, and a 13% reduction in incident CAD in a national probability sample, independent of traditional CAD risk factors.
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Details
- Title
- Effect of Positive Well-Being on Incidence of Symptomatic Coronary Artery Disease
- Creators
- Lisa R. Yanek - Johns Hopkins MedicineBrian G. Kral - Johns Hopkins MedicineTaryn F. Moy - Johns Hopkins MedicineDhananjay Vaidya - Johns Hopkins UniversityMariana Lazo - Johns Hopkins MedicineLewis C. Becker - Johns Hopkins MedicineDiane M. Becker - Johns Hopkins University
- Publication Details
- The American journal of cardiology, v 112(8), pp 1120-1125
- Publisher
- Elsevier
- Grant note
- UL1 TR000424 || TR / National Center for Advancing Translational Sciences : NCATS R01 HL058625 || HL / National Heart, Lung, and Blood Institute : NHLBI M01 RR000052 || RR / National Center for Research Resources : NCRR R01 NR008153 || NR / National Institute of Nursing Research : NINR R01 NR002241-01A1 || NR / National Institute of Nursing Research : NINR
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000325833700011
- Scopus ID
- 2-s2.0-84884905338
- Other Identifier
- 991020550498004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems