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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Effect of Pulse Shaping on Subharmonic Aided Pressure Estimation In Vitro and In Vivo
Journal of ultrasound in medicine, v 36(1), pp 3-11
Jan 2017
PMID: 27943411
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Subharmonic imaging (SHI) is a technique that uses the nonlinear oscillations of microbubbles when exposed to ultrasound at high pressures transmitting at the fundamental frequency ie, f
and receiving at half the transmit frequency (ie, f
/2). Subharmonic aided pressure estimation (SHAPE) is based on the inverse relationship between the subharmonic amplitude of the microbubbles and the ambient pressure change.
Eight waveforms with different envelopes were optimized with respect to acoustic power at which the SHAPE study is most sensitive. The study was run with four input transmit cycles, first in vitro and then in vivo in three canines to select the waveform that achieved the best sensitivity for detecting changes in portal pressures using SHAPE. A Logiq 9 scanner with a 4C curvi-linear array was used to acquire 2.5 MHz radio-frequency data. Scanning was performed in dual imaging mode with B-mode imaging at 4 MHz and a SHI contrast mode transmitting at 2.5 MHz and receiving at 1.25 MHz. Sonazoid, which is a lipid stabilized gas filled bubble of perfluorobutane, was used as the contrast agent in this study.
A linear decrease in subharmonic amplitude with increased pressure was observed for all waveforms (r from -0.77 to -0.93; P < .001) in vitro. There was a significantly higher correlation of the SHAPE gradient with changing pressures for the broadband pulses as compared to the narrowband pulses in both in vitro and in vivo results. The highest correlation was achieved with a Gaussian windowed binomial filtered square wave with an r-value of -0.95. One of the three canines was eliminated for technical reasons, while the other two produced very similar results to those obtained in vitro (r from -0.72 to -0.98; P <.01). The most consistent in vivo results were achieved with the Gaussian windowed binomial filtered square wave (r = -0.95 and -0.96).
Using this waveform is an improvement to the existing SHAPE technique (where a square wave was used) and should make SHAPE more sensitive for noninvasively determining portal hypertension.
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Details
- Title
- Effect of Pulse Shaping on Subharmonic Aided Pressure Estimation In Vitro and In Vivo
- Creators
- Ipshita Gupta - Thomas Jefferson UniversityJohn Eisenbrey - Thomas Jefferson UniversityMaria Stanczak - Thomas Jefferson UniversityAnush Sridharan - Drexel UniversityJaydev K Dave - Thomas Jefferson UniversityJi-Bin Liu - Thomas Jefferson UniversityChristopher Hazard - GE Global ResearchXinghua Wang - Department of Ultrasound, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaPing Wang - Department of Ultrasound, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaHuiwen Li - LeidosKirk Wallace - GE Global ResearchFlemming Forsberg - Thomas Jefferson UniversityMichael Stanczak - Interior Design
- Publication Details
- Journal of ultrasound in medicine, v 36(1), pp 3-11
- Grant note
- R01 DK098526 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Interior Design; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000391953600018
- Scopus ID
- 2-s2.0-85010572457
- Other Identifier
- 991019173460404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging