Journal article
Effect of Tensile Stresses on the Evolution of Post-Compaction Properties of Sodium Chloride Tablets and Its Mixtures
Journal of pharmaceutical sciences, v 109(2), pp 1115-1122
01 Feb 2020
PMID: 31733269
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study focuses on the effect of moisture on the strength of tablets of sodium chloride (NaCl) and its mixtures after compaction. We built on our prior work that proposed an explanation of the strengthening of NaCl tablets due to a dissolution-reprecipitation mechanism and the decrease in strength of NaCl-starch tablets due to the presence of residual stresses on NaCl-NaCl contacts in the mixture. Here, we offer experimental evidence that induced tensile stresses on NaCl slow down or negate (if large enough) the strengthening mechanism. Based on the idea of the negative role of tensile residual stresses in NaCl mixtures, we prove experimentally that NaCl-X mixtures can be optimized in terms of post-compaction strength, if the elastic properties of the second component in the mixture match that of NaCl. (c) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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Details
- Title
- Effect of Tensile Stresses on the Evolution of Post-Compaction Properties of Sodium Chloride Tablets and Its Mixtures
- Creators
- Jovana Radojevic - Drexel UniversityHenrietta Tsosie - Drexel UniversityAntonios Zavaliangos - Drexel University
- Publication Details
- Journal of pharmaceutical sciences, v 109(2), pp 1115-1122
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- International Fine Particle Research Institute (IFPRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000507938800024
- Scopus ID
- 2-s2.0-85076246790
- Other Identifier
- 991019168488204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy