Journal article
Effect of a 12-Month Intensive Lifestyle Intervention on Hepatic Steatosis in Adults With Type 2 Diabetes
Diabetes care, v 33(10), pp 2156-2163
01 Oct 2010
PMID: 20664019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE
Weight loss through lifestyle changes is recommended for nonalcoholic fatty liver disease (NAFLD). However, its efficacy in patients with type 2 diabetes is unproven.
RESEARCH DESIGN AND METHODS
Look AHEAD (Action for Health in Diabetes) is a 16-center clinical trial with 5,145 overweight or obese adults with type 2 diabetes, who were randomly assigned to an intensive lifestyle intervention (ILI) to induce a minimum weight loss of 7% or a control group who received diabetes support and education (DSE). In the Fatty Liver Ancillary Study, 96 participants completed proton magnetic resonance spectroscopy to quantify hepatic steatosis and tests to exclude other causes of liver disease at baseline and 12 months. We defined steatosis >5.5% as NAFLD.
RESULTS
Participants were 49% women and 68% white. The mean age was 61 years, mean BMI was 35 kg/m2, mean steatosis was 8.0%, and mean aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were 20.5 and 24.2 units/l, respectively. After 12 months, participants assigned to ILI (n = 46) lost more weight (−8.5 vs. −0.05%; P < 0.01) than those assigned to DSE and had a greater decline in steatosis (−50.8 vs. −22.8%; P = 0.04) and in A1C (−0.7 vs. −0.2%; P = 0.04). There were no significant 12-month changes in AST or ALT levels. At 12 months, 26% of DSE participants and 3% (1 of 31) of ILI participants without NAFLD at baseline developed NAFLD (P < 0.05).
CONCLUSIONS
A 12-month intensive lifestyle intervention in patients with type 2 diabetes reduces steatosis and incident NAFLD.
Metrics
Details
- Title
- Effect of a 12-Month Intensive Lifestyle Intervention on Hepatic Steatosis in Adults With Type 2 Diabetes
- Creators
- Mariana Lazo - Bloomberg (United States)Steven F. Solga - Johns Hopkins UniversityAlena Horska - Johns Hopkins UniversitySusanne Bonekamp - Johns Hopkins UniversityAnna Mae Diehl - Duke UniversityFrederick L. Brancati - Johns Hopkins UniversityLynne E. Wagenknecht - Wake Forest UniversityF. Xavier Pi-Sunyer - Columbia UniversitySteven E. Kahn - University of WashingtonJeanne M. Clarkfor the Fatty Liver Subgroup of the Look AHEAD Research Group
- Publication Details
- Diabetes care, v 33(10), pp 2156-2163
- Publisher
- American Diabetes Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000283205100005
- Scopus ID
- 2-s2.0-78149283488
- Other Identifier
- 991020550493704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism