Journal article
Effect of age on presynaptic beta 2 receptor mediated responses in the rat heart
Mechanisms of ageing and development, v 59(1)
1991
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Presynaptic alpha
2 adrenergic receptor inhibition of norepinephrine (NE) release is diminished in older animals [1]. To determine whether presynaptic beta
2 adrenergic receptor facilitation of NE release is also affected by age, the effect of propranolol on neurally-induced NE release was examined in perfused heart preparations isolated from 6- and 24-month-old rats. The heart was isolated with the right cardiac sympathetic nerve and then was stimulated electrically in the absence and presence of propranolol (10
−8–10
−6 M). NE content in the effluent was measured by an HPLC/EC methodology. The data indicate that there is a greater suppression of NE release by propranolol in preparations isolated from younger animals. For example, in nerve-heart preparations of 6-month-old animals stimulated at 12 Hz, propranolol (10
−6M) reduced the amount of NE released by 34% whereas in preparations from 24-month-old animals at 12 Hz there was no significant change in the NE overflow. Like the
alpha
2
receptor mechanism, autoregulation of NE release by presynaptic
beta
2
receptors is diminished in older animals. Lack of presynaptic autoregulation may explain in part, the reduced capacity of adrenergic influences to control and regulate cardiac function in older animals.
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Details
- Title
- Effect of age on presynaptic beta 2 receptor mediated responses in the rat heart
- Creators
- Mary L. Mortimer - York College of PennsylvaniaNihal Tumer - ArcherMark D. Johnson - York College of PennsylvaniaJay Roberts - York College of PennsylvaniaJames R Roberts - Emergency Medicine
- Publication Details
- Mechanisms of ageing and development, v 59(1)
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1991FR46800002
- Scopus ID
- 2-s2.0-0025854351
- Other Identifier
- 991019183932904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology