Journal article
Effect of aggregation on stereochemistry and mechanism of asymmetric oxidation of the lithium enolate of methyl 3,3-dimethylbutanoate in the solid state and in solution
Tetrahedron letters, v 34(23), pp 3715-3718
1993
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Oxidation of the title enolate by enantiopure (camphorylsulfonyl)oxaziridines in THF afforded α-hydroxyester with 53–73% ee, but the product from the solid state reactions was racemic. The results suggest that the enolate exists and reacts as an aggregate in the solid state reactions.
Oxidation of
1 by enantiopure
2 in THF afforded enantioenriched
3 with 53–73% ee, but
3 from the solid state reactions was recemic. The results suggest that the enolate exists and reacts as an aggregate in the solid state reactions.
Metrics
Details
- Title
- Effect of aggregation on stereochemistry and mechanism of asymmetric oxidation of the lithium enolate of methyl 3,3-dimethylbutanoate in the solid state and in solution
- Creators
- Wei Yen - Drexel UniversityR. Bakthavatchalam - Drexel UniversityJin Xian-Ming - Drexel UniversityChristopher K. Murphy - Drexel UniversityFranklin A. Davis - Drexel University
- Publication Details
- Tetrahedron letters, v 34(23), pp 3715-3718
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1993LF89800015
- Scopus ID
- 2-s2.0-0027278506
- Other Identifier
- 991019173942504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Organic