Journal article
Effect of altering smooth muscle tone on maximal expiratory flows in patients with tracheomalacia
Pediatric pulmonology, v 9(3), pp 170-176
1990
PMID: 1980538
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We obtained maximal partial expiratory flow‐volume (PEFV) curves using the rapid compression technique in three infants with intrathoracic tracheomalacia. Maximum flows were quantitated at functional residual capacity (V̇maxFRC). Studies were performed at baseline, after inhalation of methacholine (MCh) and after inhalation of albuterol. At baseline, all three patients had significantly lower than normal V̇maxFRC values, and two patients displayed expiratory flow limitation during tidal breathing. V̇maxFRC improved significantly after MCh administration, but fell back toward or below baseline after albuterol. Additionally, the ratio of forced to tidal flows at mid‐tidal volume (V̇mid(forced/tidal), a reflection of expiratory flow reserve, increased after MCh administration and decreased after albuterol. Two patients also received oral bethanechol: 2.9 mg/M2, q 8 hr for 10 days, after which PEFV curves were repeated. Both V̇maxFRC and V̇mid(forced/tidal) were increased over baseline after bethanechol administration, but decreased after albuterol. These results suggest that in patients with abnormally collapsible tracheae, stimulation of tracheal smooth muscle can improve airway stability, thereby increasing forced expiratory flows. Additionally, relaxation of airway smooth muscle by bronchodilators can have the opposite effect and exacerbate obstruction. Pediatr Pulmonal 1990; 9:170–176.
Metrics
Details
- Title
- Effect of altering smooth muscle tone on maximal expiratory flows in patients with tracheomalacia
- Creators
- Howard B PanitchEsteban N KeklikianRaymond A MotleyMarla R WolfsonDaniel V Schidlow
- Publication Details
- Pediatric pulmonology, v 9(3), pp 170-176
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; New York
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1990EC95700007
- Scopus ID
- 2-s2.0-0025579472
- Other Identifier
- 991014877975404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pediatrics
- Respiratory System