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Effect of antibody to interferon on genital herpesvirus infection in mice
Journal article   Peer reviewed

Effect of antibody to interferon on genital herpesvirus infection in mice

Helena Wrzos, Donna M. Murasko and Fred Rapp
Microbial pathogenesis, v 1(1), pp 71-78
01 Feb 1986
DOI: https://doi.org/10.1016/0882-4010(86)90033-1
PMID: 3508484
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

genital infection of mice Herpes simplex virus type 2 interferon antibody
The effect of anti-mouse interferon (IFN) antibody on the course of genital herpes infection was studied in C57BI/6J mice. As we have previously described, intravaginal inoculation of C57 mice with herpes simplex virus type 2 (HSV-2) results in the development of genital lesions, subsequent encephalitis and death, with the mortality rate dependent on virus dose. In the present study, we found that intravaginal application of 1 × 10 5 units of anti-mouse ( α β ) IFN antibody did not significantly affect the course of infection. However, intraperitoneal or intravenous injection (the latter to a lesser extent) of anti-IFN antibody resulted in increased morbidity and mortality. In addition, intraperitoneal injection of anti-IFN antibody decreased the level of detectable endogenous IFN in peripheral blood and at the site of infection. The clear effect of anti-IFN antibody during early stages of infection points to the possible significance of early endogenous IFN production in ameliorating HSV-2 genital infection.

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
Microbiology
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