Journal article
Effect of baroreceptor stimulation on the respiratory pattern: Insights into respiratory–sympathetic interactions
Respiratory physiology & neurobiology, v 174(1), pp 135-145
2010
PMID: 20837166
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sympathetic nerve activity (SNA) is modulated by respiratory activity which indicates the existence of direct interactions between the respiratory and sympathetic networks within the brainstem. Our experimental studies reveal that
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prolongation evoked by baroreceptor stimulation varies with respiratory phase and depends on the pons. We speculate that the sympathetic baroreceptor reflex, providing negative feedback from baroreceptors to the rostral ventrolateral medulla and SNA, has two pathways: one direct and independent of the respiratory–sympathetic interactions and the other operating via the respiratory pattern generator and is hence dependent on the respiratory modulation of SNA. Our experimental studies in the perfused
in situ rat preparation and complementary computational modelling studies support the hypothesis that baroreceptor activation during expiration prolongs the
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via transient activation of post-inspiratory and inhibition of augmenting expiratory neurones of the Bötzinger Complex (BötC). We propose that these BötC neurones are also involved in the respiratory modulation of SNA, and contribute to the respiratory modulation of the sympathetic baroreceptor reflex.
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Details
- Title
- Effect of baroreceptor stimulation on the respiratory pattern: Insights into respiratory–sympathetic interactions
- Creators
- David M Baekey - Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USAYaroslav I Molkov - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAJulian F.R Paton - School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UKIlya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAThomas E Dick - Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
- Publication Details
- Respiratory physiology & neurobiology, v 174(1), pp 135-145
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000284724800015
- Scopus ID
- 2-s2.0-78049412575
- Other Identifier
- 991014878399504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physiology
- Respiratory System