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Journal article
Effect of cimetidine and antacid on gastric microbial flora
Infection and immunity, v 36(2), pp 518-524
May 1982
PMID: 7085070
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Abstract
The effect of a standard regimen of cimetidine on the gastric flora of 20 male volunteers was studied in a double-blind manner and compared with the effects of a standard antacid regimen. Postprandial microbial titers in gastric aspirates were significantly higher at 4, 8, and 16 weeks of therapy in subjects taking antacids and at 4 weeks in subjects taking cimetidine when compared with their pretreatment titers. Although not significant, there was a tendency for fasting microbial titers to be higher in subjects receiving cimetidine as compared with pretreatment titers. The higher titers were primarily related to increases in survival of mouth flora (viridans streptococci and Neisseria spp.); Enterobacteriaceae and other nitrate-reducing organisms were unusual isolates. There was no significant difference in the total titers or types of organisms isolated when subjects taking cimetidine were compared with those taking antacid.
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Details
- Title
- Effect of cimetidine and antacid on gastric microbial flora
- Creators
- R SneparG A PoporadJ M RomanoW D KobasaD Kaye
- Publication Details
- Infection and immunity, v 36(2), pp 518-524
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1982NN05400012
- Scopus ID
- 2-s2.0-0020075366
- Other Identifier
- 991019184314404721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases