Journal article
Effect of depemokimab on asthma control and clinical outcomes: a systematic review and meta-analysis of randomized controlled trials
Expert review of respiratory medicine, Forthcoming
13 Jun 2026
PMID: 42268259
Abstract
Patients with eosinophilic asthma are at increased risk of poor asthma control despite optimized standard therapy. Depemokimab, a novel long-acting anti-interleukin-5 monoclonal antibody, has shown efficacy in reducing exacerbations; however, its effects across clinical outcomes have not been comprehensively synthesized.
PubMed, Embase, Cochrane databases, and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) comparing depemokimab with placebo. Outcomes included Asthma Control Questionnaire-5 (ACQ-5), asthma exacerbation rate, quality of life assessed by St. George's Respiratory Questionnaire (SGRQ), and adverse events. Results were reported as mean differences (MDs) or incidence rate ratios (IRRs) with 95% confidence intervals (CIs), and heterogeneity was assessed using the I
statistic.
Four RCTs (
= 954) were included. Depemokimab did not significantly improve ACQ-5 (MD -0.30; 95% CI -0.92 to 0.32; I
= 73.6%;
= 0.23), but reduced exacerbation rates (IRR 0.47; 95% CI 0.36 to 0.59; I
= 0%;
< 0.001) and modestly improved SGRQ scores without reaching the MCID (MD -2.80; 95% CI -5.38 to -0.23; I
= 0.0%;
= 0.033). Safety was comparable to placebo.
Depemokimab reduced exacerbations and had a comparable safety profile, but did not improve symptom control or achieve the MCID for health-related quality-of-life.
The study protocol was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO; registration number CRD420261282685).
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Details
- Title
- Effect of depemokimab on asthma control and clinical outcomes: a systematic review and meta-analysis of randomized controlled trials
- Creators
- Shun Nakahara - University of Hawaii SystemMaria Júlia Hallack Moura - Universidade Federal de Santa CatarinaSumeyye K Cengiz - Gazi UniversityManoel F Filho - Universidade Federal do Rio de JaneiroJafar Aljazeeri - Drexel University
- Publication Details
- Expert review of respiratory medicine, Forthcoming
- Publisher
- Taylor & Francis
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:001792811100001
- Other Identifier
- 991022191261004721