Journal article
Effect of drug type on the degradation rate of PLGA matrices
European journal of pharmaceutics and biopharmaceutics, v 64(3), pp 287-293
2006
PMID: 16949804
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We compare the rate of drug release through the degradation of 50:50 polylactic-co-glycolic acid polymer pellets, for six different drugs: Thiothixene, Haloperidol, Hydrochlorothiozide, Corticosterone, Ibuprofen, and Aspirin. Despite using the same polymer matrix and drug loading (20% by weight), we find that the rate of polymer degradation and the drug release profile differ significantly between the drugs. We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate.
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Details
- Title
- Effect of drug type on the degradation rate of PLGA matrices
- Creators
- Steven J. Siegel - University of PennsylvaniaJonathan B. Kahn - University of PennsylvaniaKayla Metzger - University of PennsylvaniaKaren I. Winey - University of PennsylvaniaKathryn Werner - Drexel UniversityNily Dan - Drexel University
- Publication Details
- European journal of pharmaceutics and biopharmaceutics, v 64(3), pp 287-293
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000242502200004
- Scopus ID
- 2-s2.0-33750048727
- Other Identifier
- 991019312380904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy