Journal article
Effect of extra- and intra-mitochondrial calcium on citrulline synthesis
Amino acids, v 12(3-4), pp 293-298
01 Sep 1997
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A quantitative relationship between rat liver mitochondrial matrix free Ca^sup 2+^ ([Ca^sup 2+^]^sub m^) and citrullinogenesis has been observed. Maximum citrulline synthesis occurred at 100 to 200nM [Ca^sup 2+^]^sub m^; higher [Ca^sup 2+^]^sub m^ caused inhibition. When [Ca^sup 2+^]^sub m^ was decreased to below 50nM, by addition of A23187 and EGTA, inhibition also occurred. By incubating mitochondria with ruthenium red ([Ca^sup 2+^]^sub m^ = 200nM) prior to addition of extramitochondrial free Ca^sup 2+^ ([Ca^sup 2+^]^sub o^) it was found that high external Ca^sup 2+^ (800nM) did not inhibit citrulline synthesis thus demonstrating that [Ca2+]m, not [Ca^sup 2+^]^sub o^ was controlling citrullinogenesis.[PUBLICATION ABSTRACT]
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Details
- Title
- Effect of extra- and intra-mitochondrial calcium on citrulline synthesis
- Creators
- A Saavedra-molina - Universidad Michoacana de San Nicolás de HidalgoT Devlin - Hahnemann University Hospital
- Publication Details
- Amino acids, v 12(3-4), pp 293-298
- Publisher
- Springer Nature B.V
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:A1997XG50700009
- Scopus ID
- 2-s2.0-0030808919
- Other Identifier
- 991019167540504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology