Journal article
Effect of filling gases on the backscatter from contrast microbubbles: theory and in vivo measurements
Ultrasound in medicine & biology, v 25(8), pp 1203-1211
1999
PMID: 10576263
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Abstract
Two surfactant-based contrast agents, ST44 and ST68, were produced according to US Patent # 5,352,436 and filled with either air, C
4F
10 (perfluorobutane) or SF
6 (sulfur hexaflouride). Ten rabbits received IV injections of each agent/gas combination with 5 repetitions of each dose (range: 0.005–0.13 mL/kg). A custom-made 10-MHz cuff transducer was placed around the surgically exposed distal aorta and audio Doppler signals were acquired
in vivo. Quantitative
in vivo dose responses were calculated off-line using spectral power analysis and compared to a theoretical model of microbubble dissolution and enhancement. For qualitative comparisons, 10 rabbits were imaged pre- and postcontrast administration (dose: 0.1 mL/kg) in gray-scale and colour. All agent/gas combinations produced marked Doppler enhancement with air bubbles enhancing least of all (
p < 0.0001) and ST68-SF
6 best of all (maximum: 27.6 ± 2.04 dB;
p < 0.012). There were no significant differences between other agent/gas combinations (0.30 <
p < 0.70). Theoretical enhancement was within 1 order of magnitude of the experimental observations (
i.e., deviations of up to 10 dB). The duration of contrast enhancement was 1–2 min for air-filled bubbles, 3–5 min for SF
6-filled bubbles and more than 7 min for C
4F
10-filled bubbles. In conclusion, ST68-SF
6 microbubbles produced most
in vivo enhancement of the agent/gas combinations studied. Theory matched the measurements within an order of magnitude.
Metrics
Details
- Title
- Effect of filling gases on the backscatter from contrast microbubbles: theory and in vivo measurements
- Creators
- Flemming Forsberg - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USARahguveer Basude - Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104 USAJi-Bin Liu - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USAJohn Alessandro - Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104 USAWilliam T Shi - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USANandkumar M Rawool - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USABarry B Goldberg - Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 USAMargaret A Wheatley - Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104 USA
- Publication Details
- Ultrasound in medicine & biology, v 25(8), pp 1203-1211
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000083063600005
- Scopus ID
- 2-s2.0-0032879188
- Other Identifier
- 991014878026804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging