Journal article
Effect of hepatic artery flow on bile secretory function after cold ischemia
American journal of transplantation, v 3(2), pp 148-155
Feb 2003
PMID: 12603210
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
These studies evaluated the influence of hepatic arterial flow on biliary secretion after cold ischemia. Preparation of livers for transplantation or hepatic support impairs biliary secretion. The earliest indication of cold preservation injury during reperfusion is circulatory function. Arterial flow at this time may be critical for bile secretion. Porcine livers were isolated, maintained at 4 degrees for 2 h and connected in an extracorporeal circuit to an anesthetized normal pig. The extracorporeal livers were perfused either by both the hepatic artery and portal vein (dual) or by the portal vein alone (single). Incremental doses of sodium taurocholate were infused into the portal vein of both the dual and single perfused livers, and the bile secretion was compared. Most endogenous bile acids are lost during hepatic isolation. After supplementation, the biliary secretion of phosphatidyl choline and cholesterol was significantly better in the dual than single vessel-perfused livers; however, no difference was seen in bilirubin output. Single perfused livers were completely unable to increase biliary cholesterol in response to bile acid. The dependence of bile cholesterol secretion on arterial flow indicates the importance of this flow to the detoxification of compounds dependent on phosphatidyl choline transport during early transplantation.
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Details
- Title
- Effect of hepatic artery flow on bile secretory function after cold ischemia
- Creators
- David P Foley - Department of Surgery, University of Massachusetts Medical School, MA MCP Hahnemann University School of Medicine, Philadelphia, PA, USA.Rocco Ricciardi - University of Massachusetts Medical SchoolAngela N Traylor - University of Massachusetts Medical SchoolThomas J McLaughlin - University of Massachusetts Medical SchoolSusan E Donohue - University of Massachusetts Medical SchoolSuzanne M Wheeler - University of Massachusetts Medical SchoolWilliam C Meyers - Hahnemann University HospitalSteven H Quarfordt - University of Massachusetts Medical School
- Publication Details
- American journal of transplantation, v 3(2), pp 148-155
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000181454700007
- Scopus ID
- 2-s2.0-0037297087
- Other Identifier
- 991019167454104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery
- Transplantation