Journal article
Effect of increasing age on adrenergic control of heart rate in the rat
Experimental gerontology, v 23(2), pp 115-125
1988
PMID: 3136028
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine if decreased cardiac rate with increasing age in Fischer-344 rats was due to changes in the heart itself, in adrenergic nerves innervating the heart or in both, we studied heart rate in vivo and in vitro, and atrial and ventricular pacemaker activity in vitro following atrioventricular block, in control and in chemically sympathectomized rats [pretreated with 6-hydroxydopamine (6-OHDA), 20 mg/kg, s.c., 24 h prior to testing] at ages 1 to 28 months. With increasing age, heart rate (bpm) in vivo decreased from 440 ± 12 to 385 ± 10 in the control and from 403 ± 20 to 318 ± 11 in 6-OHDA pretreated rats; heart rate in vitro decreased from 353 ± 9 to 243 ± 8 in the control, and from 346 ± 15 to 214 ± 18 in 6-OHDA pretreated rats; the atrial rate (AR)_decreased from 304 ± 9 to 210 ± 8 in the control and from 288 ± 13 to 161 ± 32 in 6-OHDA pretreated rats while the ventricular pacemaker rate (VR) decreased from 121 ±8 to 92 ± 5 in the control, and from 100 ± 14 to 70 ± 7 in 6-OHDA pretreated rats. With age, AR decreased to a greater extent than VR and 6-OHDA had a greater effect in decreasing AR than VR. Using cardiac rate as a measure, it appears that with age changes in the pacemakers of the heart themselves (postjunctional) as well as in the adrenergic nerve endings innervating the heart (prejunctional) contribute to decreased cardiac rate and peacemaker activity in older rats.
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Details
- Title
- Effect of increasing age on adrenergic control of heart rate in the rat
- Creators
- Paula Bursztyn Goldberg - Smith Kline and French Laboratories, Clinical Research and Development, West L233, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USANihal TumerJay Roberts - Drexel UniversityJames R Roberts - Emergency Medicine
- Publication Details
- Experimental gerontology, v 23(2), pp 115-125
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1988N535700005
- Scopus ID
- 2-s2.0-0023915688
- Other Identifier
- 991019184193504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology