Journal article
Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes
American journal of perinatology, v 32(4), pp 387-392
Mar 2015
PMID: 25241107
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study aims to evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes (PPROM) between 24 and 31(6/7) weeks' gestation.
This is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between 24 and 31(6/7) weeks' gestation with PPROM without evidence of labor were randomized to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour up to 12 hours, or placebo. Maternal outcomes for this analysis were delivery in less than 48 hours and in less than 7 days from randomization. Neonatal outcomes included a composite of respiratory distress syndrome, interventricular hemorrhage grades 3 or 4, periventricular leukomalacia, sepsis, necrotizing enterocolitis, retinopathy of prematurity, or death.
A total of 1,259 women were included. The rate of delivery < 48 hours was not different in the magnesium sulfate and the placebo groups (22.2 and 20.7%, p = 0.51). Delivery < 7 days was similar between groups (55.4 and 51.4%, p = 0.16). Median latency was also similar between groups (median [interquartile range], 6.0 days [range, 2.4-13.8 days] and 6.6 days [range, 2.4-15.1 days], p = 0.29). Composite neonatal outcomes did not differ between groups.
Magnesium sulfate administration given for neuroprotection in women with a singleton gestation with PPROM and without labor before 32 weeks does not impact latency.
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Details
- Title
- Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes
- Creators
- Amanda L Horton - University of ChicagoYinglei Lai - George Washington UniversityDwight J Rouse - University of Alabama at BirminghamCatherine Y Spong - National Institutes of HealthKenneth J Leveno - The University of Texas Southwestern Medical CenterMichael W Varner - University of UtahBrian M Mercer - Case Western Reserve UniversityJay D Iams - The Ohio State UniversityRonald J Wapner - Thomas Jefferson UniversityYoram Sorokin - Wayne State UniversityJohn M Thorp - University of North CarolinaSusan M Ramin - The University of Texas at AustinFergal D Malone - Columbia UniversityMary J O'Sullivan - University of Miami*Gary D V Hankins - The University of Texas Medical Branch at GalvestonSteve N Caritis - University of PittsburghEunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units NetworkYiling Lai - Design
- Publication Details
- American journal of perinatology, v 32(4), pp 387-392
- Publisher
- Thieme
- Grant note
- HD40485 / NICHD NIH HHS U10 HD027860 / NICHD NIH HHS U10 HD027915 / NICHD NIH HHS HD34136 / NICHD NIH HHS U10 HD021410 / NICHD NIH HHS UG1 HD027915 / NICHD NIH HHS UG1 HD034116 / NICHD NIH HHS HD21414 / NICHD NIH HHS HD40545 / NICHD NIH HHS HD53907 / NICHD NIH HHS M01 RR000080 / NCRR NIH HHS U10 HD034116 / NICHD NIH HHS HD40544 / NICHD NIH HHS HD27861 / NICHD NIH HHS U10 HD053097 / NICHD NIH HHS HD27917 / NICHD NIH HHS HD40560 / NICHD NIH HHS U10 HD034208 / NICHD NIH HHS UG1 HD040485 / NICHD NIH HHS U10 HD027917 / NICHD NIH HHS HD21410 / NICHD NIH HHS UG1 HD040560 / NICHD NIH HHS HD27915 / NICHD NIH HHS UG1 HD040544 / NICHD NIH HHS UG1 HD040512 / NICHD NIH HHS UG1 HD027869 / NICHD NIH HHS U10 HD027905 / NICHD NIH HHS U10 HD034136 / NICHD NIH HHS U10 HD034122 / NICHD NIH HHS HD34210 / NICHD NIH HHS HD27860 / NICHD NIH HHS UG1 HD040545 / NICHD NIH HHS U10 HD040500 / NICHD NIH HHS HD27869 / NICHD NIH HHS MO1-RR-000080 / NCRR NIH HHS HD34208 / NICHD NIH HHS UG1 HD040500 / NICHD NIH HHS U10 HD036801 / NICHD NIH HHS U10 HD040545 / NICHD NIH HHS U10 HD040544 / NICHD NIH HHS U10 HD040512 / NICHD NIH HHS HD36801 / NICHD NIH HHS HD40512 / NICHD NIH HHS U10 HD027869 / NICHD NIH HHS HD34116 / NICHD NIH HHS U10 HD040560 / NICHD NIH HHS U01 HD019897 / NICHD NIH HHS UG1 HD034208 / NICHD NIH HHS U10 HD040485 / NICHD NIH HHS HD40500 / NICHD NIH HHS U01 HD036801 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Design
- Web of Science ID
- WOS:000351664400012
- Scopus ID
- 2-s2.0-84925359388
- Other Identifier
- 991019173453604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics