Journal article
Effect of mefenidil hydrochloride on cerebral blood flow in conscious and anesthetized rat
Pharmacology, Vol.33(3), pp.167-180
01 Jan 1986
Abstract
The purpose of this study was to determine the effects of the putative cerebral vasodilator, mefenidil hydrochloride (MF), on cardiocirculatory dynamics and the total distribution of cardiac output in the conscious rat. Neither MF nor vehicle (VH) were found to have significant effects on cerebral blood flow or vascular resistance in conscious rats. MF significantly increased cerebral blood flow and lowered cerebral vascular resistance compared to VH in anesthetized animals without having significant effects in other circulatory regions.
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Details
- Title
- Effect of mefenidil hydrochloride on cerebral blood flow in conscious and anesthetized rat
- Creators
- S FlaimM StranieriJ MathiasenM D Brannan
- Publication Details
- Pharmacology, Vol.33(3), pp.167-180
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Identifiers
- 991021900017404721