Logo image
Back
Effect of monoamineoxidase inhibitors on 5‐hydroxytryptamine output from perfused cerebral ventricles of anaesthetized cats
Journal article   Open access   Peer reviewed

Effect of monoamineoxidase inhibitors on 5‐hydroxytryptamine output from perfused cerebral ventricles of anaesthetized cats

CECILIE A. Goodrich
British journal of pharmacology, v 37(1), 87
Sep 1969
DOI: https://doi.org/10.1111/j.1476-5381.1969.tb09525.x
PMID: 4390487
url
https://doi.org/10.1111/j.1476-5381.1969.tb09525.xView
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

In cats anaesthetized with pentobarbitone sodium, intraperitoneal injections of four inhibitors of monoamine oxidase (MAO) were shown to increase the 5‐hydroxytryptamine (5‐HT) in the effluent from the perfused cerebral ventricles. . Weight for weight, tranylcypromine was found to be about twice as potent as pheniprazine, eight times as potent as nialamide and sixty times as potent as pargyline. . The effect of tranylcypromine was also examined after reserpine had been injected into the cerebral ventricles or after p ‐chlorophenylalanine, given intraperitoneally. In both conditions tranylcypromine retained its ability to increase the 5‐HT output from the perfused cerebral ventricle, but the effect was attenuated, more after p ‐chlorophenylalanine than after reserpine. . Evidence is put forward that in both conditions the brain is not completely depleted of its 5‐HT, but that the 5‐HT is only reduced, more after p ‐chlorophenylalanine than after reserpine.

Metrics

5 Record Views
16 citations in Web of Science
11 citations in Scopus

Details

Logo image