Journal article
Effect of morphine and SIV on dendritic cell trafficking into the central nervous system of rhesus macaques
Journal of neurovirology, v 20(2)
Apr 2014
PMID: 23943466
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recruitment of immune cells such as monocytes/macrophages and dendritic cells (DCs) across the blood-brain barrier (BBB) has been documented in diseases involving neuroinflammation. Neuroinvasion by HIV leads to neurocognitive diseases and alters the permeability of the BBB. Likewise, many HIV patients use drugs of abuse such as morphine, which can further compromise the BBB. While the role of monocytes and macrophages in neuroAIDS is well established, research demonstrating the presence and role of DCs in the CNS during HIV infection has not been developed yet. In this respect, this study explored the presence of DCs in the brain parenchyma of rhesus macaques infected with a neurovirulent form of SIV (SIV mac239 R71/17E) and administered with morphine. Cells positive for DC markers including CD11c (integrin), macDC-SIGN (dendritic cell-specific ICAM-3 grabbing nonintegrin), CD83 (a maturation factor) and HLA-DR (MHC class II) were consistently found in the brain parenchyma of SIV-infected macaques as well as infected macaques on morphine. Control animals did not exhibit any DC presence in their brains. These results provide first evidence of DCs’ relevance in NeuroAIDS vis-à-vis drugs of abuse and open new avenues of understanding and investigative HIV-CNS inflictions.
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Details
- Title
- Effect of morphine and SIV on dendritic cell trafficking into the central nervous system of rhesus macaques
- Creators
- Rebecca Hollenbach - Department of Microbiology and Immunology Drexel University College of Medicine, Philadelphia, PADivya Sagar - Department of Microbiology and Immunology Drexel University College of Medicine, Philadelphia, PAZafar K Khan - Department of Microbiology and Immunology Drexel University College of Medicine, Philadelphia, PAShannon Callen - Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NEHonghong Yao - Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NEJasmine Shirazi - Department of Microbiology and Immunology Drexel University College of Medicine, Philadelphia, PAShilpa Buch - Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NEPooja Jain - Department of Microbiology and Immunology Drexel University College of Medicine, Philadelphia, PA
- Publication Details
- Journal of neurovirology, v 20(2)
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000334196300009
- Scopus ID
- 2-s2.0-84898854057
- Other Identifier
- 991014878380704721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Virology