Journal article
Effect of oligomeric derivatives of prostaglandin B 1 on oxidative phosphorylation and their Ca 2+ ionophoretic activity
Biochemical and biophysical research communications, v 137(1)
1986
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Abstract
Dimers, trimers and tetramers of 15-dehydro-PGB
1 and of 16,16′-dimethyl-15-dehydro-PGB
1 have been synthesized and their effect on mitochondrial function evaluated. The trimers and tetramers, and to a lesser extent the dimers, of both series, protected isolated mitochondria from the loss of phosphorylating capacity during in vitro incubation. The monomers were inactive. The trimers and tetramers inhibited between 40 and 50% the F
1F
0-ATPase of submitochondrial particles. All of the oligomers, but not the monomers, had Ca
2+ ionophoretic activity with isolated mitochondria. These activities are qualitatively similar to that reported for the oligomeric mixture of 15-dehydro-PGB
1, termed PGB
X.
Metrics
Details
- Title
- Effect of oligomeric derivatives of prostaglandin B 1 on oxidative phosphorylation and their Ca 2+ ionophoretic activity
- Creators
- Thomas M. Devlin - Hahnemann University HospitalRosita Krupinski-Olsen - Hahnemann University HospitalSalvador Uribe - Hahnemann University HospitalGeorge E. Nelson - Saint Joseph's University
- Publication Details
- Biochemical and biophysical research communications, v 137(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:A1986C606800032
- Scopus ID
- 2-s2.0-0022536446
- Other Identifier
- 991019184296404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics