Journal article
Effect of polymer characteristics on structure of polymer–liposome complexes
Journal of colloid and interface science, v 311(1), pp 243-252
2007
PMID: 17382337
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the current study, we examined the effect of polymer characteristics on the structure of complexes formed between poly(methacrylic acid-
co-
n-alkyl methacrylate) and with phosphatidylcholine/cholesterol liposomes. We varied the polymer concentration in the vesicles, the preparation concentration of lipid and polymer components during preparation, the molecular weight of the polymer chain, the molecular weight of the polymer's hydrophobic side groups and their mole fraction. The vesicle behavior indicated polymer-free bilayers and bilayers complexed with polymer coexisted at low polymer concentrations. As the polymer concentration exceeds a critical level, however, the system became homogeneous, indicating bilayer uniformity of the bilayer. As the polymer content was raised, the vesicle size and fluidity increased, and the transition temperature decreased. We found that the vesicle size mostly affects the membrane fluidity. We also found that the thermal properties (transition temperature and the magnitude of heat capacity of the peak,
Δ
C
p
) are governed by the effects of the polymer on the structure of bilayer. The length of the alkyl chain of the polymer is shown to significantly affect the structure of polymer–liposome complexes, as did the chain molecular weight and mole concentration of hydrophobic group in the polymer.
Changes in the concentration and structure of amphiphilic polymer influence the structure of polymer–liposome complex.
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Details
- Title
- Effect of polymer characteristics on structure of polymer–liposome complexes
- Creators
- Eun Chul Cho - AmorepacificHyung Jun Lim - AmorepacificJongwon Shim - AmorepacificJu Young Park - AmorepacificNily Dan - Drexel UniversityJunoh Kim - AmorepacificIh-Seop Chang - AmorepacificJinWon Kim - Chemical and Biological Engineering
- Publication Details
- Journal of colloid and interface science, v 311(1), pp 243-252
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000246925700029
- Scopus ID
- 2-s2.0-34247473134
- Other Identifier
- 991019173467404721
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- Web of Science research areas
- Chemistry, Physical