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Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia
Journal article   Open access   Peer reviewed

Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia

Said Aboud, Gernard Msamanga, Jennifer S. Read, Lei Wang, Chelu Mfalila, Usha Sharma, Francis Martinson, Taha E. Taha, Robert L. Goldenberg and Wafaie W. Fawzi
International journal of gynecology and obstetrics, v 107(3), pp 202-207
28 Aug 2009
DOI: https://doi.org/10.1016/j.ijgo.2009.07.037
PMID: 19716560
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.ijgo.2009.07.037View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

HIV Maternal morbidity Maternal mortality Antibiotics Pregnancy
We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women. A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20–24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26–30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used. There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort. Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women.

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17 citations in Web of Science
15 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Obstetrics & Gynecology
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