Journal article
Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles
Ultrasound in medicine & biology, v 30(10), pp 1281-1287
2004
PMID: 15582227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study compared
in vivo enhancement from four different polymer-encapsulated ultrasound (US) contrast agents. The agents were produced with a rigid shell composed of the biodegradable block copolymer poly[
d,l-lactide-
co-glycolide] (PLGA) with the lactic and glycolic acid ratios 50:50, 75:25, 85:15 and 100:0 (i.e., increasingly hydrophobic shell compositions). Approximately the same bubble diameter (1.2 μm) and concentration (0.4 g/mL) were obtained for each agent. In four rabbits, audio Doppler signals were acquired from a 10 MHz cuff transducer placed around a surgically exposed vessel (contrast dose: 0.0125 to 0.15 mL/kg).
In vivo dose responses were calculated off-line (in dB). Nine rabbit kidneys were imaged during contrast administration (0.1 mL/kg) in power Doppler and grey-scale pulse inversion harmonic (PIHI) modes using an HDI 5000 scanner (Philips Medical Systems, Bothell, WA). Time-intensity curves were produced and the time-to-peak, peak intensity, slope, area under the curve (AUC) and total duration of enhancement for each agent were compared. All agents produced marked Doppler enhancement with increasing duration from the 50:50 agent (48 ± 10 s) to the 75:25 agent (166 ± 46 s), the 85:15 agent (403 ± 83 s) and with the 100:0 agent (603 ± 93 s) lasting longest (
p < 0.02). No other parameters changed significantly, except the AUC of the 85:15 agent, which was greater than that of the 50:50 agent (190.75 vs. 61.58;
p = 0.02). The
in vivo dose-response curves were similar for all agents, with mean enhancement up to 20.6 ± 1.11 dB (
p = 0.17). In conclusion, contrast duration increases by an order of magnitude as the lactic acid component in the polymer-encapsulated bubbles increases and the shell, thus, becomes increasingly hydrophobic. (E-mail:
flemming.forsberg@jefferson.edu)
Metrics
Details
- Title
- Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles
- Creators
- Flemming Forsberg - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USAJustin D Lathia - School of Biomedical Engineering, Drexel University, Philadelphia, PA, USADaniel A Merton - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USAJi-Bin Liu - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USANgocyen T Le - School of Biomedical Engineering, Drexel University, Philadelphia, PA, USABarry B Goldberg - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USAMargaret A Wheatley - School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA
- Publication Details
- Ultrasound in medicine & biology, v 30(10), pp 1281-1287
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000225557100003
- Scopus ID
- 2-s2.0-9644269227
- Other Identifier
- 991014878400604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging