Journal article
Effect of short-term corticosteroid usage on acute urinary toxicity following Cs-131 prostate brachytherapy
Brachytherapy, v 21(4), pp 468-474
01 Jul 2022
PMID: 35514004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate short-term patient reported urinary quality of life scores in patients with prostate cancer treated at our institution with and without perioperative prednisone following Cesium-131 (131Cs) prostate LDR brachytherapy.
We started routinely using a perioperative 7-day course of prednisone at a dose of 5 mg per day, beginning 1 day prior to 131Cs prostate LDR brachytherapy from 2013 with goal of improving acute urinary symptomatology. One hundred consecutive patients treated with prednisone were selected, with comparison to 100 consecutive patients who were not treated with prednisone. We analyzed for differences in mean change with standard deviation (SD) in EPIC and AUA scores at 0.5–1 month and 3 months with or without prednisone by Mann-Whitney U Test. Binary logistic regression was performed to assess for impact of prednisone on postoperative urinary catheter use.
Pretreatment EPIC and AUA scores were available in 197 patients. Less reduction in EPIC US score was noted at 0.5–1.0 month in the group who received prednisone with mean change of -22.9 (SD 15.4) when compared to the group who did not receive prednisone with mean change of -31.7 (SD 19.3), p < 0.01, with significance lost at 3 months. There was no significant difference in acute urinary retention requiring postoperative urinary catheter placement with perioperative prednisone (OR 1.13, p = 0.71).
A short course of perioperative low-dose prednisone was associated with less severe worsening in urinary symptoms by the EPIC questionnaire at the 0.5–1.0-month timepoint suggesting some improvement in acute urinary quality of life, although differences did not remain statistically significant at 3 months.
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Details
- Title
- Effect of short-term corticosteroid usage on acute urinary toxicity following Cs-131 prostate brachytherapy
- Creators
- Andrew Keller - UPMC Hillman Cancer CenterMohamed Abdelhakiem - UPMC Hillman Cancer CenterRia Mulherkar - UPMC Hillman Cancer CenterSiddharth Ghanta - University of PittsburghRonald Benoit - University of Pittsburgh School of MedicineRyan P. Smith - UPMC Hillman Cancer CenterSushil Beriwal - Allegheny Health Network
- Publication Details
- Brachytherapy, v 21(4), pp 468-474
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000827588400011
- Scopus ID
- 2-s2.0-85129436204
- Other Identifier
- 991021897258404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging