Journal article
Effect of temperature and loading on the structure of β-casein/ibuprofen assemblies
Journal of colloid and interface science, v 449, pp 514-521
01 Jul 2015
PMID: 25754442
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
[Display omitted]
β-Casein is a 24kDa amphiphilic and unstructured protein that self-assembles into small core–shell micelles at a wide range of concentrations, pH values and temperatures. We recently developed the micelles as nanocarriers for oral delivery of hydrophobic drugs. In this paper we examined the effect of the hydrophobic non-steroidal anti-inflammatory drug (NSAID) ibuprofen on the micellar structure, as a function of temperature and loading. Using cryo-transmission electron microscopy (cryo-TEM) we find two routes of organization – mixed micellization and co-assembly (aggregation). The time-dependent events that characterize the second routes has been examined in detail. At 25°C we find coexistence of small assemblies and larger aggregates of irregular (but defined) structures that contain the drug. Increasing the drug loading increases the relative number of the larger aggregates and their dimensions, leading eventually to the formation of long then branched structures, like in amphiphilic block copolymer solutions. Similar trends were identified for changes in the temperature. Combined, our results suggest that ibuprofen acts as a co-surfactant that possibly is localizes to the interface rather than being encapsulated in the micellar core as other NSAID hydrophobic drugs.
Metrics
Details
- Title
- Effect of temperature and loading on the structure of β-casein/ibuprofen assemblies
- Creators
- Tanya Turovsky - Technion – Israel Institute of TechnologyIrina Portnaya - Technion – Israel Institute of TechnologyEllina Kesselman - Technion – Israel Institute of TechnologyInbal Ionita-Abutbul - Technion – Israel Institute of TechnologyNily Dan - Drexel UniversityDganit Danino - Technion – Israel Institute of Technology
- Publication Details
- Journal of colloid and interface science, v 449, pp 514-521
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000353848300061
- Scopus ID
- 2-s2.0-84940004357
- Other Identifier
- 991019312443204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Physical