Journal article
Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS
Brain research. Molecular brain research., v 130(1)
2004
PMID: 15519671
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transgenic mice expressing multiple copies of the G93A mutant form of SOD1 develop motor neuron pathology and clinical symptoms similar to those seen in patients with amyotrophic lateral sclerosis (ALS). The phenotype of these mice is dependent on the number of transgene copies in their genome. Changes in transgene copy number, although rare, can sometimes occur while mating due to intra locus recombination events during meiosis. The objective of this study was to develop a real time quantitative PCR method to determine changes in transgene copy number in these mice and to evaluate the effect of transgene copy number on the phenotype of the G93A SOD1 mouse model of ALS.
Metrics
Details
- Title
- Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS
- Creators
- Guillermo M Alexander - Department of Neurology, College of Medicine, Drexel University, Mail stop 423, 245 North 15th Street, Philadelphia, PA 19102, United StatesKirsten L Erwin - Department of Neurology, College of Medicine, Drexel University, Mail stop 423, 245 North 15th Street, Philadelphia, PA 19102, United StatesNathaniel Byers - Department of Neurology, College of Medicine, Drexel University, Mail stop 423, 245 North 15th Street, Philadelphia, PA 19102, United StatesJeffrey S Deitch - Department of Neurology, College of Medicine, Drexel University, Mail stop 423, 245 North 15th Street, Philadelphia, PA 19102, United StatesBrian J Augelli - Department of Neurology, School of Medicine, Temple University, Parkinson Pavilion, Suite 558, 3401 N. Broad Street, Philadelphia, PA 19140, United StatesElizabeth P Blankenhorn - Department of Microbiology and Immunology, College of Medicine, Drexel University, 245 North 15th Street, Philadelphia, PA 19102, United StatesTerry D Heiman-Patterson - Department of Neurology, College of Medicine, Drexel University, Mail stop 423, 245 North 15th Street, Philadelphia, PA 19102, United States
- Publication Details
- Brain research. Molecular brain research., v 130(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000225167600002
- Scopus ID
- 2-s2.0-7444237149
- Other Identifier
- 991014877801004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences