Logo image
Back
Effect of vitamin B6 supplementation on plasma oxalate and oxalate removal rate in hemodialysis patients
Journal article   Open access

Effect of vitamin B6 supplementation on plasma oxalate and oxalate removal rate in hemodialysis patients

J F Costello, M C Sadovnic, M Smith and C Stolarski
Journal of the American Society of Nephrology, v 3(4), pp 1018-1024
Oct 1992
DOI: https://doi.org/10.1681/ASN.V341018
PMID: 1450364
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1681/asn.v341018View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Alanine Transaminase - blood Creatinine - blood Humans Hyperoxaluria - etiology Hyperoxaluria - prevention & control Kidney Calculi - prevention & control Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Oxalates - blood Pyridoxine - pharmacology Pyridoxine - therapeutic use Renal Dialysis Uremia - complications Vitamin B 6 Deficiency - complications Vitamin B 6 Deficiency - drug therapy
Whether pyridoxine (B6) supplements decrease plasma oxalate concentrations in patients on maintenance dialysis is unresolved. The effect of two dose levels of B6, 0.59 mmol/day (100 mg/day) over 6 months and 4.43 mmol (750 mg) after each dialysis treatment for 4 wk, on plasma oxalate and oxalate removal rate (dialysis plus urinary excretion) was studied in patients on maintenance hemodialysis. In both studies, a control group unsupplemented with B6, who remained on their regular diet, was also studied. The vitamin B6 status of the patients was assessed by the erythrocyte glutamate pyruvate transaminase activity and index before and during supplementation. No decrease in plasma oxalate or oxalate removal rate was found in either study. The plasma oxalate and oxalate removal rates of the unsupplemented hemodialysis patients were not different from those receiving B6 either before or after supplementation. These studies demonstrate that high-dose B6 supplementation does not decrease plasma oxalate concentration in a population of hemodialysis patients.

Metrics

10 Record Views
8 citations in Web of Science

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Urology & Nephrology
Logo image