Journal article
Effective {alpha}-Particle-mediated Radioimmunotherapy of Murine Leukemia
Cancer Research, v 52(20), p5818
15 Oct 1992
PMID: 1394209
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Departments of Comparative Medicine [R. B. H., R. A. S.] and Pharmacology [M. S.], Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and Inorganic and Radioimmune Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 [G. G. P., M. W. B., O. A. G.]
The specificity, toxicity, and efficacy of -particle-mediated radioimmunotherapy of murine erythroleukemia was assessed by use of tumorspecific monoclonal antibody 103A labeled with 212 Bi. Forty % of the injected dose/g tissue targeted to neoplastic spleens within 1 h after i.v. injection. When 212 Bi-103A was injected on day 13 of disease, a dose-dependent response was achieved, as measured by a reduction in splenomegaly and absence of liver metastasis. Mice treated with 212 Bi-103A on day 8 of disease showed no histological evidence of erythroleukemia on day 22 and survived significantly longer (median, 118 days) than mice treated with 212 Bi-control IgG (78 days) or untreated mice (63 days), indicating successful specific radioimmunotherapy.
1 This research was supported in part by NIH Grants RR007002 and RR00130.
2 To whom requests for reprints should be addressed.
Received 7/10/92.
Accepted 8/28/92.
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Details
- Title
- Effective {alpha}-Particle-mediated Radioimmunotherapy of Murine Leukemia
- Creators
- Richard B HunekeC. Greg PippinRobert A SquireMartin W BrechbielOtto A GansowMette Strand
- Publication Details
- Cancer Research, v 52(20), p5818
- Publisher
- AACR
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1992JU45800039
- Scopus ID
- 2-s2.0-0026737729
- Other Identifier
- 991021463604404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology