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Effectiveness and Safety of Transcatheter Closure of Perimembranous Ventricular Septal Defects in Adults
Journal article   Peer reviewed

Effectiveness and Safety of Transcatheter Closure of Perimembranous Ventricular Septal Defects in Adults

Jianming Wang, Jian Zuo, Shiqiang Yu, Dinghua Yi, Xiuling Yang, Xianyang Zhu, Jun Li, Lifang Yang, Lize Xiong, Shuping Ge, …
The American journal of cardiology, v 117(6), pp 980-987
15 Mar 2016
DOI: https://doi.org/10.1016/j.amjcard.2015.12.036
PMID: 26796197
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adolescent Adult Aged Atrioventricular Block - etiology Cardiac Catheterization - adverse effects Cardiac Catheterization - instrumentation Echocardiography Female Follow-Up Studies Heart Septal Defects, Ventricular - diagnostic imaging Heart Septal Defects, Ventricular - mortality Heart Septal Defects, Ventricular - therapy Humans Kaplan-Meier Estimate Male Middle Aged Patient Safety Prosthesis Design Retrospective Studies Risk Assessment Risk Factors Septal Occluder Device - adverse effects Time Factors Treatment Outcome Tricuspid Valve Insufficiency - etiology
This study was designed to determine the long-term safety and efficacy of using modified double-disk occluders for perimembranous ventricular septal defect (pmVSD) closure in adults. From January 2004 to December 2014, 337 adults with pmVSDs were treated through transcatheter intervention using 2 types of double-disk occluders; 302 patients received a symmetrical concentric pmVSD occluder, and 35 patients received an asymmetrical concentric pmVSD occluder. All patients were followed up through electrocardiography and transthoracic echocardiography until June 2015. The success rate was 100% for both procedures. During the median 71-month follow-up period, no cases of infective endocarditis, cerebrovascular accidents, heart failure, or death occurred. Two major adverse events (0.6%) were recorded: complete atrioventricular block requiring surgical treatment in one patient and severe tricuspid valvular regurgitation requiring surgical repair in another patient. Cardiac conduction block was the most common minor adverse event. The mean left ventricular (LV) end-diastolic volume decreased from 96.6 ± 23.2 ml before intervention to 86.0 ± 22.0 ml (p <0.05) at the 6-month follow-up visit. Previously enlarged LV chambers decreased to normal sizes during the follow-up period. In conclusion, transcatheter closure of pmVSDs using modified double-disk occluders was both safe and effective and yielded excellent long-term results in adults. The potential benefits of this intervention included remodeling of the heart, a reduced incidence of infective endocarditis and prevention of LV volume overload.

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13 citations in Web of Science
17 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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