Journal article
Effectiveness of Cefotaxime in Gram-negative Meningitis
Neurosurgery, v 15(5), pp 679-682
01 Nov 1984
PMID: 6095133
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
We treated 12 adult patients who had gram-negative bacillary meningitis with cefotaxime administered intravenously at a dose of 2 g every 4 hours. The etiological organisms included Haemophilus influenzae (3 cases), Serratia marcescens (3 cases), Klebsiella pneumoniae (3 cases), Escherichia coli (2 cases), and Enterobacter (1 case). The infection followed a neurosurgical procedure in 6 cases. The mean inhibitory and bactericidal concentrations of cefotaxime for the isolates ranged from 0.125 to 0.25 ug/ml. The cerebrospinal fluid (CSF) concentrations of cefotaxime ranged from 5.0 to 15.2 ug/ml, and the CSF bactericidal titers were 1:64 to 1:128. The CSF in all patients was sterilized within 96 hours. All 12 patients recovered, and there were no relapses.
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Details
- Title
- Effectiveness of Cefotaxime in Gram-negative Meningitis
- Creators
- Jack L. LeFrock - Drexel UniversityAbdolghader Molavi - Drexel UniversityBruce Smith - Drexel UniversityPerry Black - Department of Neurosurgery, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaManuel Rosenberg - Division of Infectious Diseases and Clinical Microbiology, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaKenneth Rolston - Division of Infectious Diseases and Clinical Microbiology, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaRobert Brodner - Department of Neurosurgery, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaPranatharthi Chandrasekar - Division of Infectious Diseases and Clinical Microbiology, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaLibia Henao - Division of Infectious Diseases and Clinical Microbiology, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaDon W. Kannangara - Division of Infectious Diseases and Clinical Microbiology, Hahnemann University School of Medicine, Philadelphia, PennsylvaniaMichael D Rosenberg - School of Education (1997-)
- Publication Details
- Neurosurgery, v 15(5), pp 679-682
- Publisher
- LWW
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Education
- Web of Science ID
- WOS:A1984TR88000007
- Scopus ID
- 2-s2.0-0021749346
- Other Identifier
- 991019184095404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Surgery