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Effects of Aerosolized Adenosine 5'-Triphosphate in Smokers and Patients With COPD
Journal article   Peer reviewed

Effects of Aerosolized Adenosine 5'-Triphosphate in Smokers and Patients With COPD

Ozen K Basoglu, Peter J Barnes, Sergei A Kharitonov and Amir Pelleg
Chest, v 148(2), pp 430-435
Aug 2015
DOI: https://doi.org/10.1378/chest.14-2285
PMID: 25590209
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adenosine Monophosphate - adverse effects Adenosine Monophosphate - pharmacology Adenosine Triphosphate - adverse effects Adenosine Triphosphate - pharmacology Administration, Inhalation Adult Breath Tests Bronchi - drug effects Bronchoconstriction - drug effects Case-Control Studies Cough - chemically induced Dyspnea - chemically induced Female Humans Male Middle Aged Pulmonary Disease, Chronic Obstructive - physiopathology Severity of Illness Index Smoking - physiopathology
Extracellular adenosine 5'-triphosphate (ATP) stimulates vagal C and Aδ fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients with COPD and compared these responses to the effects of inhaled adenosine, the metabolite of ATP. We studied the effects of inhaled ATP and adenosine monophosphate (AMP) on airway caliber, perception of dyspnea assessed by the Borg score, cough sensitivity, and ATP in exhaled breath condensate in healthy nonsmokers (n = 10), healthy smokers (n = 14), and patients with COPD (n = 7). In comparison with healthy subjects, ATP induced more dyspnea, cough, and throat irritation in smokers and patients with COPD, and the effects of ATP were more pronounced than those of AMP. The concentration of ATP in the exhaled breath condensate of patients with COPD was elevated compared with that of healthy subjects. Smokers and patients with COPD manifest hypersensitivity to extracellular ATP, which may play a mechanistic role in COPD.

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44 citations in Web of Science
41 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Critical Care Medicine
Respiratory System
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