Journal article
Effects of Antihypertensive Therapy During Pregnancy on Postpartum Blood Pressure Control
Obstetrics and gynecology (New York. 1953), v 144(4), pp 536-542
Oct 2024
PMID: 39265175
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antihypertensive treatment of mild chronic hypertension during pregnancy is associated with improved postpartum blood pressure control.
OBJECTIVE:To compare differences in postpartum blood pressure (BP) control (BP below 140/90 mm Hg) for participants with hypertension randomized to receive antihypertensive treatment compared with no treatment during pregnancy.METHODS:This study was a planned secondary analysis of a multicenter, open-label, randomized controlled trial (The CHAP [Chronic Hypertension and Pregnancy] trial). Pregnant participants with mild chronic hypertension (BP below 160/105 mm Hg) were randomized into two groups: active (antihypertensive treatment) or control (no treatment unless severe hypertension, BP 160/105 mm Hg or higher). Study outcomes were BP control below 140/90 mm Hg (primary) and medication nonadherence based on a composite score threshold (secondary) at the 6-week postpartum follow-up visit. Participants without follow-up BP measurements were excluded from analysis of the BP control outcome. Participants without health care professional-prescribed antihypertensives at delivery were excluded from the analysis of the adherence outcome. Multivariable logistic regression was used to adjust for potential confounders.RESULTS:Of 2,408 participants, 1,684 (864 active, 820 control) were included in the analysis. A greater percentage of participants in the active group achieved BP control (56.7% vs 51.5%; adjusted odds ratio [aOR] 1.22, 95% CI, 1.00-1.48) than in the control group. Postpartum antihypertensive prescription was higher in the active group (81.7% vs 58.4%, P<.001), and nonadherence did not differ significantly between groups (aOR 0.81, 95% CI, 0.64-1.03).CONCLUSION:Antihypertensive treatment of mild chronic hypertension during pregnancy was associated with better BP control below 140/90 mm Hg in the immediate postpartum period.
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Details
- Title
- Effects of Antihypertensive Therapy During Pregnancy on Postpartum Blood Pressure Control
- Creators
- Samantha L. Martin - University of North Carolina at Chapel HillHui-Chien KuoKim BoggessLorraine DugoffBaha SibaiKirsten LawrenceBrenna L. HughesJoseph BellKjersti AagaardKelly S. GibsonDavid M. HaasLauren PlanteTorri D. MetzBrian M. CaseySean EsplinSherri LongoMatthew HoffmanGeorge R. SaadeJanelle ForoutanMethodius G. TuuliMichelle Y. OwensHyagriv N. SimhanHeather A. FreyTodd RosenAnna PalatnikSusan BakerPhyllis AugustUma M. ReddyWendy KinzlerEmily J. SuIris KrishnaNicki NguyenMary E. NortonDaniel SkupskiYasser Y. El-SayedDotun OgunyemiZorina S. GalisNamasivayam AmbalavananSuzanne OparilRonald LibrizziLeonardo PereiraEverett F. MagannMounira HabliShauna WilliamsGiancarlo MariGabriella PridjianDavid S. McKennaMarc ParrishEugene ChangSarah OsmundsonJoAnne QuinonesErika WernerJeff M. SzychowskiAlan T. N. Titafor the CHAP Consortium
- Publication Details
- Obstetrics and gynecology (New York. 1953), v 144(4), pp 536-542
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- KL2TR003097 / National Center for Advancing Translational Sciences (https://doi.org/10.13039/100006108) 5U01HL120338 / National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Obstetrics and Gynecology
- Web of Science ID
- WOS:001341163200013
- Scopus ID
- 2-s2.0-85204375235
- Other Identifier
- 991022202095404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology