Journal article
Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection
Cells (Basel, Switzerland), v 13(10), p882
01 May 2024
PMID: 38786105
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV infection is an ongoing global health issue, despite increased access to antiretroviral therapy (ART). People living with HIV (PLWH) who are virally suppressed through ART still experience negative health outcomes, including neurocognitive impairment. It is increasingly evident that ART may act independently or in combination with HIV infection to alter the immune state, though this is difficult to disentangle in the clinical population. Thus, these experiments used multiplexed chemokine/cytokine arrays to assess peripheral (plasma) and brain (nucleus accumbens; NAc) expression of immune targets in the presence and absence of ART treatment in the EcoHIV mouse model. The findings identify the effects of EcoHIV infection and of treatment with bictegravir (B), emtricitabine (F), and tenofovir alafenamide (TAF) on the expression of numerous immune targets. In the NAc, this included EcoHIV-induced increases in IL-1α and IL-13 expression and B/F/TAF-induced reductions in KC/CXCL1. In the periphery, EcoHIV suppressed IL-6 and LIF expression, while B/F/TAF reduced IL-12p40 expression. In the absence of ART, IBA-1 expression was negatively correlated with CX3CL1 expression in the NAc of EcoHIV-infected mice. These findings identify distinct effects of ART and EcoHIV infection on peripheral and central immune factors and emphasize the need to consider ART effects on neural and immune outcomes.
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Details
- Title
- Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection
- Creators
- Qiaowei Xie - Drexel UniversityMark D Namba - Drexel UniversityLauren A Buck - Drexel UniversityKyewon Park - University of PennsylvaniaJoshua G Jackson - Drexel UniversityJacqueline M Barker - Drexel University
- Publication Details
- Cells (Basel, Switzerland), v 13(10), p882
- Publisher
- MDPI
- Grant note
- 1R03DA047919-01A1 / NIH HHS 1DP2DA051907-01A1 / NIH HHS 1R21DA056309-01A1 / NIH HHS 1R01AG081929-01 / NIH HHS 5P30MH092177-09A1 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001232293100001
- Scopus ID
- 2-s2.0-85194127828
- Other Identifier
- 991021881389304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology