Journal article
Effects of Canavanine Treatment on Herpesvirus Morphogenesis in Cultured Cells
Intervirology, v 16(4), pp 233-243
01 Jan 1981
PMID: 6282774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
L-Canavanine, a naturally occurring analog of arginine, effectively inhibited the morphogenesis of herpes simplex virus (HSV) and human cytomegalovirus (HCMV) when added at the time of infection, but allowed the expression of several cytopathic changes. Exposure to canavanine at progressively later times ultimately led to qualitatively normal virion maturation. Under no conditions were morphologically aberrant viral particles observed. However, HSV-infected cells treated at 3 h postinfection or later did contain distinctive cytoplasmic inclusions resembling HCMV dense bodies. Recovery experiments showed that HCMV-infected cells exposed to canavanine for 1–5 days could support normal viral morphogenesis when washed free of this agent.
Metrics
Details
- Title
- Effects of Canavanine Treatment on Herpesvirus Morphogenesis in Cultured Cells
- Creators
- Janet D. Smith - Drexel UniversityDorothy M. Moore - Drexel University
- Publication Details
- Intervirology, v 16(4), pp 233-243
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1981NK68500004
- Scopus ID
- 2-s2.0-0019802621
- Other Identifier
- 991021900202704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Virology