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Journal article
Effects of Chronic High-Frequency rTMS Protocol on Respiratory Neuroplasticity Following C2 Spinal Cord Hemisection in Rats
Biology (Basel, Switzerland), v 11(3), p473
01 Mar 2022
PMID: 35336846
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Simple Summary High spinal cord injuries (SCIs) are known to lead to permanent diaphragmatic paralysis, and to induce deleterious post-traumatic inflammatory processes following cervical spinal cord injury. We used a noninvasive therapeutic tool (repetitive transcranial magnetic stimulation (rTMS)), to harness plasticity in spared descending respiratory circuit and reduce the inflammatory processes. Briefly, the results obtained in this present study suggest that chronic high-frequency rTMS can ameliorate respiratory dysfunction and elicit neuronal plasticity with a reduction in deleterious post-traumatic inflammatory processes in the cervical spinal cord post-SCI. Thus, this therapeutic tool could be adopted and/or combined with other therapeutic interventions in order to further enhance beneficial outcomes. High spinal cord injuries (SCIs) lead to permanent diaphragmatic paralysis. The search for therapeutics to induce functional motor recovery is essential. One promising noninvasive therapeutic tool that could harness plasticity in a spared descending respiratory circuit is repetitive transcranial magnetic stimulation (rTMS). Here, we tested the effect of chronic high-frequency (10 Hz) rTMS above the cortical areas in C2 hemisected rats when applied for 7 days, 1 month, or 2 months. An increase in intact hemidiaphragm electromyogram (EMG) activity and excitability (diaphragm motor evoked potentials) was observed after 1 month of rTMS application. Interestingly, despite no real functional effects of rTMS treatment on the injured hemidiaphragm activity during eupnea, 2 months of rTMS treatment strengthened the existing crossed phrenic pathways, allowing the injured hemidiaphragm to increase its activity during the respiratory challenge (i.e., asphyxia). This effect could be explained by a strengthening of respiratory descending fibers in the ventrolateral funiculi (an increase in GAP-43 positive fibers), sustained by a reduction in inflammation in the C1-C3 spinal cord (reduction in CD68 and Iba1 labeling), and acceleration of intracellular plasticity processes in phrenic motoneurons after chronic rTMS treatment. These results suggest that chronic high-frequency rTMS can ameliorate respiratory dysfunction and elicit neuronal plasticity with a reduction in deleterious post-traumatic inflammatory processes in the cervical spinal cord post-SCI. Thus, this therapeutic tool could be adopted and/or combined with other therapeutic interventions in order to further enhance beneficial outcomes.
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Details
- Title
- Effects of Chronic High-Frequency rTMS Protocol on Respiratory Neuroplasticity Following C2 Spinal Cord Hemisection in Rats
- Creators
- Pauline Michel-Flutot - University of Paris-SaclayIsley Jesus - University of Paris-SaclayValentin Vanhee - University of Paris-SaclayCamille H. Bourcier - University of Paris-SaclayLaila Emam - University of Paris-SaclayAbderrahim Ouguerroudj - University of Paris-SaclayKun-Ze Lee - National Sun Yat-sen UniversityLyandysha Zholudeva - Gladstone InstitutesMichael A. Lane - Drexel UniversityArnaud Mansart - University of Paris-SaclayMarcel Bonay - University of Paris-SaclayStephane Vinit - University of Paris-Saclay
- Publication Details
- Biology (Basel, Switzerland), v 11(3), p473
- Publisher
- Mdpi
- Number of pages
- 18
- Grant note
- INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm); European Commission Chancellerie des Universites de Paris (Legs Poix) R01 NS104291; F32 NS119348 / National Institutes of Health, NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 109-2636-B-110-001 / Ministry of Science and Technology Universite de Versailles Saint-Quentin-en-Yvelines Fondation de France Fondation Medisite Lisa Dean Moseley Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000776799700001
- Scopus ID
- 2-s2.0-85127547735
- Other Identifier
- 991019169007904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology