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Journal article
Effects of Diet on Sensitization to Cocaine-Induced Stereotypy in Female Rats
Pharmacology, biochemistry and behavior, v 58(3), pp 683-688
1997
PMID: 9329059
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Abstract
The progressive increase in cocaine-induced stereotyped behavior that accompanies repeated cocaine injections (sensitization) was examined in rats consuming different diets. Adult female Sprague–Dawley rats were fed one of three diets: low protein (6% casein), adequate protein (25% casein), or a standard chow diet. Following 1 week of adaptation to the diets, the rats were injected every 3–4 days with either cocaine (30 mg/kg, IP) or saline, and the total amount of stereotypy was measured over a 90-min interval following each of four injections. Cocaine-induced stereotypy peaked at 40–50 min following each injection, after which it declined for all diet groups. With repeated injections, the total amount of stereotypy increased in all diet groups. By the fourth injection, the low protein diet group (6% casein) exhibited a slower onset and a possibly prolonged duration of cocaine-induced stereotypy when compared with the two adequate protein diet groups (25% casein and chow). Interestingly, the rats in the two purified diet groups (6% casein and 25% casein) exhibited significantly more stereotypy across injections than those in the chow diet group. Weight differences did not explain the differences in stereotypy present among the diet groups. This study concludes that diet significantly alters the pattern of cocaine-induced stereotypy in female rats, especially after repeated exposure.
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Details
- Title
- Effects of Diet on Sensitization to Cocaine-Induced Stereotypy in Female Rats
- Creators
- Jed S Shumsky - Center for Behavioral Development & Mental Retardation, M923 Boston University School of Medicine, 80 E. Concord St., Boston, MA 02118 USAPenny L Shultz - Center for Behavioral Development & Mental Retardation, M923 Boston University School of Medicine, 80 E. Concord St., Boston, MA 02118 USAJohn Tonkiss - Center for Behavioral Development & Mental Retardation, M923 Boston University School of Medicine, 80 E. Concord St., Boston, MA 02118 USAJanina R Galler - Center for Behavioral Development & Mental Retardation, M923 Boston University School of Medicine, 80 E. Concord St., Boston, MA 02118 USA
- Publication Details
- Pharmacology, biochemistry and behavior, v 58(3), pp 683-688
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XZ34400011
- Scopus ID
- 2-s2.0-0030754730
- Other Identifier
- 991014878515304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy