Journal article
Effects of Diethylstilbestrol on Propionibacterium acnes Immunomodulation: Inhibition of Macrophage Activation and Antitumor Activity
Journal of leukocyte biology, v 40(5), pp 549-559
Nov 1986
PMID: 2430037
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Exposure of mice to diethylstilbestrol (DES) inhibited Propionibacterium acnes‐induced antitumor activity in vivo against the B16F10 subcutaneous tumor. The inhibitory effect was associated with inhibition by DES of the characteristic P. acnes induced splenomegaly and changes in splenic and peritoneal macrophages (Mφ) cell populations. The characteristic P. acnes induced reductions in Mφ alkaline phosphodiesterase I (APD) ectoenzyme activity and in total RNA synthesis, proposed biochemical markers of tumoricidal Mφ, were partially or completely reversed in DES‐treated mice. As predicted from these in vivo and in vitro results, DES treatment significantly decreased P. acnes activation of Mφ antitumor activity in vitro against B16F10 melanoma and Lewis lung carcinoma cells. These data suggest a macrophage activation defect may be involved in the reduced resistance that DES‐treated animals exhibit to a variety of neoplastic and microbial challenges.
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Details
- Title
- Effects of Diethylstilbestrol on Propionibacterium acnes Immunomodulation: Inhibition of Macrophage Activation and Antitumor Activity
- Creators
- Michael F. Ackermann - Departments of Microbiology and Immunology (M.F.A., P.R.C., P.S.M.)Raymond Mark - Drexel UniversityPrasanta R. Chakraborty - Departments of Microbiology and Immunology (M.F.A., P.R.C., P.S.M.)Page S. Morahan - Departments of Microbiology and Immunology (M.F.A., P.R.C., P.S.M.)
- Publication Details
- Journal of leukocyte biology, v 40(5), pp 549-559
- Publisher
- Wiley
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1986E427000005
- Scopus ID
- 2-s2.0-0022452245
- Other Identifier
- 991019184299204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Hematology
- Immunology