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Journal article
Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction
International journal of molecular sciences, v 23(12), 6575
12 Jun 2022
PMID: 35743018
Abstract
Early life exposure to sex hormones affects several brain areas involved in regulating locomotor and motivation behaviors. Our group has shown that neonatal exposure to testosterone propionate (TP) or estradiol valerate (EV) affected the brain dopamine (DA) system in adulthood. Here, we studied the long-lasting effects of neonatal exposure to sex hormones on behavioral and neurochemical responses to amphetamine (AMPH) and methylphenidate (MPD). Our results show that AMPH-induced locomotor activity was higher in female than male control rats. The conditioned place preference (CPP) to AMPH was only observed in EV male rats. In EV female rats, AMPH did not increase locomotor activity, but MPD-induced CPP was observed in control, EV and TP female rats. Using in vivo brain microdialysis, we observed that AMPH-induced extracellular DA levels were lower in nucleus accumbens (NAcc) of EV and TP female rats than control rats. In addition, MPD did not increase NAcc extracellular DA levels in EV rats. Using in vivo fast-scan cyclic voltammetry in striatum, MPD-induced DA reuptake was higher in EV than control rats. In summary, our results show that early life exposure to sex hormones modulates mesolimbic and nigrostriatal DA neurons producing opposite neurochemical effects induced by psychostimulant drugs in NAcc or striatum.
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Details
- Title
- Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction
- Creators
- Maximiliano Elgueta-Reyes - University of ValparaísoVictoria B. Velasquez - Univ Valparaiso, Fac Ciencias, Ctr Neurobiol & Fisiopatol Integrat CENFI, Inst Fisiol,Lab Neuroquim & Neurofarmacol, Valparaiso 2360102, ChilePedro Espinosa - University of ValparaísoRaul Riquelme - University of ValparaísoTatiana Dib - University of ValparaísoNicole K. Sanguinetti - University of ValparaísoAngelica P. Escobar - Univ Valparaiso, Fac Ciencias, Ctr Neurobiol & Fisiopatol Integrat CENFI, Inst Fisiol,Lab Neuroquim & Neurofarmacol, Valparaiso 2360102, ChileJonathan Martinez-Pinto - University of ValparaísoGeorgina M. Renard - Univ Santiago Chile, Fac Ciencias Med, Ctr Invest Biomed & Aplicada CIBAP, Escuela Med, Santiago 9170022, ChileRodrigo A Espana - University of ValparaísoRamon Sotomayor-Zarate - Univ Valparaiso, Fac Ciencias, Ctr Neurobiol & Fisiopatol Integrat CENFI, Inst Fisiol,Lab Neuroquim & Neurofarmacol, Valparaiso 2360102, Chile
- Publication Details
- International journal of molecular sciences, v 23(12), 6575
- Publisher
- Mdpi
- Number of pages
- 12
- Grant note
- 116-0398; 120-0474 / National Agency of Research and Development (ANIDChile) through FONDECYT 01/2006 / DIUV-CI Grant
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000818466900001
- Scopus ID
- 2-s2.0-85131695738
- Other Identifier
- 991022005885704721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary